Evidence map›Paper›PMID 37759988›Full record

ArticleAntioxidants (Basel, Switzerland)2023

Selenomethionine Attenuated H

Lingyu Xie, Yibin Xu, Xiaoqing Ding, Kaixuan Li, Shuang Liang, Danlei Li, Yongxia Wang, Aikun Fu, Weixiang Yu, Xiuan Zhan

Open access · goldAbstract read
In one paragraph

Article in Antioxidants (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.0field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 6 citations in OpenAlex.

  1. SOD1 Overexpression Alleviates HAntioxidants (Basel, Switzerland) · 2026
    Article
  2. Heterogeneous CRISPR/Cas9 Editing ofInternational journal of molecular sciences · 2026
    Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Selenomethionine Mitigates Effects ofInternational journal of molecular sciences · 2024
    Article
  8. Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Lingyu XieMinistry of Agriculture and Key Laboratory of Animal Feed and Nutrition of Zhejiang Province, Key Laboratory of Animal Nutrition and Feed in East China, Feed Science Institute, College of Animal Science, Zhejiang University, Hangzhou 310058, China.
Yibin XuMinistry of Agriculture and Key Laboratory of Animal Feed and Nutrition of Zhejiang Province, Key Laboratory of Animal Nutrition and Feed in East China, Feed Science Institute, College of Animal Science, Zhejiang University, Hangzhou 310058, China.
Xiaoqing DingMinistry of Agriculture and Key Laboratory of Animal Feed and Nutrition of Zhejiang Province, Key Laboratory of Animal Nutrition and Feed in East China, Feed Science Institute, College of Animal Science, Zhejiang University, Hangzhou 310058, China.
Kaixuan LiMinistry of Agriculture and Key Laboratory of Animal Feed and Nutrition of Zhejiang Province, Key Laboratory of Animal Nutrition and Feed in East China, Feed Science Institute, College of Animal Science, Zhejiang University, Hangzhou 310058, China.ORCID 0000-0002-6370-8968
Shuang LiangMinistry of Agriculture and Key Laboratory of Animal Feed and Nutrition of Zhejiang Province, Key Laboratory of Animal Nutrition and Feed in East China, Feed Science Institute, College of Animal Science, Zhejiang University, Hangzhou 310058, China.
Danlei LiMinistry of Agriculture and Key Laboratory of Animal Feed and Nutrition of Zhejiang Province, Key Laboratory of Animal Nutrition and Feed in East China, Feed Science Institute, College of Animal Science, Zhejiang University, Hangzhou 310058, China.
Yongxia WangKey Laboratory of Applied Technology on Green-Eco-Healthy Animal Husbandry of Zhejiang Province, College of Animal Science and Technology, College of Veterinary Medicine, Zhejiang A & F University, Hangzhou 311300, China.
Aikun FuMinistry of Agriculture and Key Laboratory of Animal Feed and Nutrition of Zhejiang Province, Key Laboratory of Animal Nutrition and Feed in East China, Feed Science Institute, College of Animal Science, Zhejiang University, Hangzhou 310058, China.
Weixiang YuAnimal Husbandry and Veterinary Services Center of Haiyan, Jiaxing 314300, China.
Xiuan ZhanMinistry of Agriculture and Key Laboratory of Animal Feed and Nutrition of Zhejiang Province, Key Laboratory of Animal Nutrition and Feed in East China, Feed Science Institute, College of Animal Science, Zhejiang University, Hangzhou 310058, China.
Feed Research Institute · CNZhejiang A & F University · CN

Funding

China Agriculture Research System of MOF and MARA CARS-41National Natural Science Foundation of China 31572422the Key R & D program of Zhejiang Province 2023C02026
6 · The paper itself

Abstract

Earlier studies have shown that selenomethionine (SM) supplements in broiler breeders had higher deposition in eggs, further reduced the mortality of chicken embryos, and exerted a stronger antioxidant ability in offspring than sodium selenite (SS). Since previous studies also confirmed that Se deposition in eggs was positively correlated with maternal supplementation, this study aimed to directly investigate the antioxidant activities and underlying mechanisms of SS and SM on the chicken hepatocellular carcinoma cell line (LMH). The cytotoxicity results showed that the safe concentration of SM was up to 1000 ng/mL, while SS was 100 ng/mL. In Se treatments, both SS and SM significantly elevated mRNA stability and the protein synthesis rate of glutathione peroxidase (GPx) and thioredoxin reductase (TrxR), two Se-containing antioxidant enzymes. Furthermore, SM exerted protective effects in the H

Indexed as

antioxidantsglutathione peroxidaseNrf2selenomethioninesodium selenite

Identifiers

PMID37759988
PMCPMC10525281
OpenAlexW4386250665

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.