Evidence map›Paper›PMID 37759949›Full record

ArticleBrain sciences2023

The Roles of Potassium and Calcium Currents in the Bistable Firing Transition.

Fernando S Borges, Paulo R Protachevicz, Diogo L M Souza, Conrado F Bittencourt, Enrique C Gabrick, Lucas E Bentivoglio, José D Szezech, Antonio M Batista, Iberê L Caldas, Salvador Dura-Bernal and 1 more

Erratum issuedOpen access · goldAbstract read
In one paragraph

Article in Brain sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 2 countries.

Fernando S BorgesDepartment of Physiology and Pharmacology, State University of New York Downstate Health Sciences University, Brooklyn, NY 11203, USA.ORCID 0000-0002-7647-2341
Paulo R ProtacheviczInstitute of Physics, University of São Paulo, São Paulo 05508-090, Brazil.ORCID 0000-0003-4956-5259
Diogo L M SouzaGraduate Program in Science, State University of Ponta Grossa, Ponta Grossa 84010-330, Brazil.ORCID 0009-0007-0007-1238
Conrado F BittencourtGraduate Program in Science, State University of Ponta Grossa, Ponta Grossa 84010-330, Brazil.ORCID 0000-0002-2932-8304
Enrique C GabrickGraduate Program in Science, State University of Ponta Grossa, Ponta Grossa 84010-330, Brazil.ORCID 0000-0002-8407-7675
Lucas E BentivoglioGraduate Program in Science, State University of Ponta Grossa, Ponta Grossa 84010-330, Brazil.ORCID 0009-0004-5348-5213
José D SzezechGraduate Program in Science, State University of Ponta Grossa, Ponta Grossa 84010-330, Brazil.ORCID 0000-0001-8306-8315
Antonio M BatistaGraduate Program in Science, State University of Ponta Grossa, Ponta Grossa 84010-330, Brazil.ORCID 0000-0002-5899-0591
Iberê L CaldasInstitute of Physics, University of São Paulo, São Paulo 05508-090, Brazil.ORCID 0000-0002-1748-0106
Salvador Dura-BernalDepartment of Physiology and Pharmacology, State University of New York Downstate Health Sciences University, Brooklyn, NY 11203, USA.ORCID 0000-0002-8561-5324
Rodrigo F O PenaDepartment of Biological Sciences, Florida Atlantic University, Jupiter, FL 33458, USA.ORCID 0000-0002-2037-9746
Universidade Estadual de Ponta Grossa · BRUniversidade de São Paulo · BRNathan Kline Institute for Psychiatric Research · USRutgers, The State University of New Jersey · USState University of New York · US

Funding

Dissemination of a tool for data-driven multiscale modeling of brain circuitsU24EB028998 · NIBIB · SUNY DOWNSTATE MEDICAL CENTER · PI DURA-BERNAL, SALVADOR · 2019 to 2023
$1.6M
NIBIB NIH HHS U24 EB028998
6 · The paper itself

Abstract

Healthy brains display a wide range of firing patterns, from synchronized oscillations during slow-wave sleep to desynchronized firing during movement. These physiological activities coexist with periods of pathological hyperactivity in the epileptic brain, where neurons can fire in synchronized bursts. Most cortical neurons are pyramidal regular spiking (RS) cells with frequency adaptation and do not exhibit bursts in current-clamp experiments (in vitro). In this work, we investigate the transition mechanism of spike-to-burst patterns due to slow potassium and calcium currents, considering a conductance-based model of a cortical RS cell. The joint influence of potassium and calcium ion channels on high synchronous patterns is investigated for different synaptic couplings (gsyn) and external current inputs (

Indexed as

bistabilityburst synchronizationfiring pattern transitionhysteresision channels

Identifiers

PMID37759949
PMCPMC10527161
OpenAlexW4386879153

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.