Evidence map›Paper›PMID 37759913›Full record

ArticleBrain sciences2023

Treadmill Training Plus Semi-Immersive Virtual Reality in Parkinson's Disease: Results from a Pilot Study.

Massimo Pullia, Laura Ciatto, Giuseppe Andronaco, Concetta Donato, Rosario Ermes Aliotta, Angelo Quartarone, Maria Cristina De Cola, Mirjam Bonanno, Rocco Salvatore Calabrò, Roberta Cellini

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in Brain sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07434089 (Gut-Brain Axis and Rehabilitation), which is not on this map. Cited by 15 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 5 pooled it
4.2field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07434089 narecruitingnot on this mapstarted 2025, after this paper: background citation

Gut-Brain Axis and Rehabilitation: Study on the Effects of C-Mill Technology on the Intestinal Microbiota of Parkinson's Disease Patients

TypeinterventionalSponsorIRCCS Centro Neurolesi Bonino PulejoRan2025 to 2028Enrolled60ConditionsParkinson DiseaseArmsC-Mill technology treadmill equipped with semi-immersive VR, C-Mill treatment without semi-immersive virtual reality (VR), Conventional physiotherapy training
3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 5 syntheses or guidelines pooled it, 19 citations in OpenAlex.

  1. Pooled it
  2. Can virtual reality interventions reduce falls in Parkinson's disease? A systematic review and meta-analysis of randomized trials.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Massimo PulliaIRCCS Centro Neurolesi "Bonino-Pulejo", S.S. 113, Cda Casazza, 98124 Messina, Italy.
Laura CiattoIRCCS Centro Neurolesi "Bonino-Pulejo", S.S. 113, Cda Casazza, 98124 Messina, Italy.
Giuseppe AndronacoIRCCS Centro Neurolesi "Bonino-Pulejo", S.S. 113, Cda Casazza, 98124 Messina, Italy.
Concetta DonatoIRCCS Centro Neurolesi "Bonino-Pulejo", S.S. 113, Cda Casazza, 98124 Messina, Italy.
Rosario Ermes AliottaIRCCS Centro Neurolesi "Bonino-Pulejo", S.S. 113, Cda Casazza, 98124 Messina, Italy.
Angelo QuartaroneIRCCS Centro Neurolesi "Bonino-Pulejo", S.S. 113, Cda Casazza, 98124 Messina, Italy.
Maria Cristina De ColaIRCCS Centro Neurolesi "Bonino-Pulejo", S.S. 113, Cda Casazza, 98124 Messina, Italy.ORCID 0000-0002-7509-3833
Mirjam BonannoIRCCS Centro Neurolesi "Bonino-Pulejo", S.S. 113, Cda Casazza, 98124 Messina, Italy.ORCID 0000-0002-3284-9741
Rocco Salvatore CalabròIRCCS Centro Neurolesi "Bonino-Pulejo", S.S. 113, Cda Casazza, 98124 Messina, Italy.ORCID 0000-0002-8566-3166
Roberta CelliniIRCCS Centro Neurolesi "Bonino-Pulejo", S.S. 113, Cda Casazza, 98124 Messina, Italy.
Centro Neurolesi Bonino Pulejo · IT

Funding

Ministry of Health Italy This research does not have a grant number.
6 · The paper itself

Abstract

Parkinson's disease (PD) is one of the most common neurodegenerative disorders that causes postural instability and gait alterations, such as reduced walking speed, shorter step length, and gait asymmetry, exposing patients to a higher risk of falling. Recently, virtual reality (VR) was added to a treadmill, in order to promote motor functional recovery and neuroplastic processes. Twenty PD patients were enrolled and randomly assigned to two groups: the experimental group (EG) and the control group (CG). In particular, patients in the EG were trained with the C-Mill, an innovative type of treadmill, which is equipped with semi-immersive VR, whereas the CG performed conventional physiotherapy. Patients in both groups were evaluated through a specific motor assessment battery at baseline (T0) and after the training (T1). Comparing pre-(T0) and post-(T1) treatment scores, in the EG, we found statistical significances in the following outcome measures: 6 Minutes Walking Test (6MWT) (

Indexed as

C-MillneurorehabilitationParkinson’s diseasesemi-immersive virtual reality

Identifiers

PMID37759913
PMCPMC10526302
OpenAlexW4386712463

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.