Evidence map›Paper›PMID 37759809›Full record

ReviewBiomolecules2023

Mitochondrial Calcium Overload Plays a Causal Role in Oxidative Stress in the Failing Heart.

Haikel Dridi, Gaetano Santulli, Laith Bahlouli, Marco C Miotto, Gunnar Weninger, Andrew R Marks

Open access · goldAbstract readReview
In one paragraph

Review in Biomolecules, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed
6.2field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 40 citations in OpenAlex.

  1. Single-Residue Substitution of Opicalcin1 Enhances Cellular Uptake but Reduces CaChembiochem : a European journal of chemical biology · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Haikel DridiDepartment of Physiology and Cellular Biophysics, Clyde and Helen Wu Center for Molecular Cardiology, Columbia University Vagelos College of Physicians & Surgeons, New York, NY 10032, USA.
Gaetano SantulliDepartment of Medicine, Division of Cardiology, Wilf Family Cardiovascular Research Institute, Albert Einstein College of Medicine, New York, NY 10461, USA.ORCID 0000-0001-7231-375X
Laith BahlouliDepartment of Physiology and Cellular Biophysics, Clyde and Helen Wu Center for Molecular Cardiology, Columbia University Vagelos College of Physicians & Surgeons, New York, NY 10032, USA.
Marco C MiottoDepartment of Physiology and Cellular Biophysics, Clyde and Helen Wu Center for Molecular Cardiology, Columbia University Vagelos College of Physicians & Surgeons, New York, NY 10032, USA.
Gunnar WeningerDepartment of Physiology and Cellular Biophysics, Clyde and Helen Wu Center for Molecular Cardiology, Columbia University Vagelos College of Physicians & Surgeons, New York, NY 10032, USA.
Andrew R MarksDepartment of Physiology and Cellular Biophysics, Clyde and Helen Wu Center for Molecular Cardiology, Columbia University Vagelos College of Physicians & Surgeons, New York, NY 10032, USA.
Columbia University · USAlbert Einstein College of Medicine · US

Funding

Exploring the Molecular Physiology of Atrial FibrillationR01HL140934 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MARKS, ANDREW ROBERT, MARX, STEVEN O · 2018 to 2025
$6.0M
Training in Cardiovascular Translational ResearchT32HL120826 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MARKS, ANDREW ROBERT, TABAS, IRA A · 2014 to 2023
$4.7M
Structure-function analysis for elucidating pathogenicity of cardiac ryanodine receptor genetic variantsR01HL145473 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MARKS, ANDREW ROBERT, SHEPARD, KENNETH L · 2019 to 2022
$3.1M
Calcium and the Pathophysiology of Neurodegenerative DisordersRF1NS114570 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MARKS, ANDREW ROBERT · 2020 to 2020
$2.3M
Ryanodine Receptor Defects in Cardiomyopathy Caused by Lamin A/C Gene MutationsR01HL142903 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MARKS, ANDREW ROBERT, WORMAN, HOWARD J · 2019 to 2022
$1.8M
Calcium and the physiology of diabetesR01DK118240 · NIDDK · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MARKS, ANDREW ROBERT · 2019 to 2022
$1.6M
Training in Cardiovascular Sciences for Under Represented StudentsR25HL156002 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MARKS, ANDREW ROBERT · 2021 to 2025
$624k
NHLBI NIH HHS R01 HL140934NHLBI NIH HHS R01 HL142903NHLBI NIH HHS R01 HL145473NHLBI NIH HHS R25 HL156002NHLBI NIH HHS T32 HL120826NIDDK NIH HHS R01 DK118240NINDS NIH HHS RF1 NS114570
6 · The paper itself

Abstract

Heart failure is a serious global health challenge, affecting more than 6.2 million people in the United States and is projected to reach over 8 million by 2030. Independent of etiology, failing hearts share common features, including defective calcium (Ca

Indexed as

CalciumHeart FailureExcitation Contraction CouplingHumansMitochondria, HeartMyocytes, CardiacOxidative StressCalciumcalciumheart failuremitochondria

Identifiers

PMID37759809
PMCPMC10527470
OpenAlexW4386895757

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.