Aptamer-Based Proteomics Measuring Preoperative Cerebrospinal Fluid Protein Alterations Associated with Postoperative Delirium.
Simon T Dillon, Sarinnapha M Vasunilashorn, Hasan H Otu, Long Ngo, Tamara Fong, Xuesong Gu, Michele Cavallari, Alexandra Touroutoglou, Mouhsin Shafi, Sharon K Inouye and 3 more
Article in Biomolecules, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 2 pooled it
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literature
Who cites it
5 citing papers in PubMed, 2 syntheses or guidelines pooled it, 10 citations in OpenAlex.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
13 authors at 4 institutions in 1 country.
Simon T DillonDivision of Interdisciplinary Medicine and Biotechnology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA.ORCID 0000-0002-4417-178X
Sarinnapha M VasunilashornHarvard Medical School, Boston, MA 02215, USA.
Hasan H OtuDepartment of Electrical and Computer Engineering, University of Nebraska-Lincoln, Lincoln, NE 68588, USA.
Long NgoHarvard Medical School, Boston, MA 02215, USA.
Tamara FongHarvard Medical School, Boston, MA 02215, USA.
Xuesong GuDivision of Interdisciplinary Medicine and Biotechnology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA.
Michele CavallariHarvard Medical School, Boston, MA 02215, USA.
Alexandra TouroutoglouHarvard Medical School, Boston, MA 02215, USA.
Mouhsin ShafiHarvard Medical School, Boston, MA 02215, USA.
Sharon K InouyeAging Brain Center, Marcus Institute for Aging Research, Hebrew Senior Life, Boston, MA 02131, USA.
Edward R MarcantonioHarvard Medical School, Boston, MA 02215, USA.
Towia A LibermannDivision of Interdisciplinary Medicine and Biotechnology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA.ORCID 0000-0002-4006-8179
Beth Israel Deaconess Medical Center · USHarvard University · USBrigham and Women's Hospital · USUniversity of Nebraska–Lincoln · US
Funding
The Role of Inflammation in the Pathophysiology of Delirium and its Associated Long-Term Cognitive DeclineP01AG031720 · NIA · HEBREW REHABILITATION CENTER FOR AGED · PI TRAVISON, THOMAS GLENN · 2010 to 2022
$26.7M
Advancing the Understanding of Postoperative Delirium Mechanisms via Multi-OmicsR01AG051658 · NIA · BETH ISRAEL DEACONESS MEDICAL CENTER · PI TOWIA A. LIBERMANN, EDWARD R MARCANTONIO · 2016 to 2026
$5.9M
NIDUS III: Advanced-Stage Development and Utilization of the NIDUS Research Infrastructure to Advance Interdisciplinary Aging Research inDeliriumR33AG071744 · NIA · JOHNS HOPKINS UNIVERSITY · PI John W. Devlin, Esther Seunghee Oh · 2021 to 2026
$4.7M
Postoperative Delirium and Alzheimer's Disease Related DementiasR01AG062509 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI XIE, ZHONGCONG · 2019 to 2023
$3.7M
Brain Vulnerability in Delirium and Alzheimer’s Disease and Related Dementias: Intersection of Polygenic Risk and InflammationR01AG079864 · NIA · BETH ISRAEL DEACONESS MEDICAL CENTER · PI SARINNAPHA VASUNILASHORN · 2023 to 2026
$3.3M
Mid-Career Mentoring Award for Patient-Oriented Research in AgingK24AG035075 · NIA · BETH ISRAEL DEACONESS MEDICAL CENTER · PI MARCANTONIO, EDWARD R · 2010 to 2021
$1.9M
TMS in Primary Progressive Aphasia: Modulation of Brain Networks and LanguageK23DC016912 · NIDCD · MASSACHUSETTS GENERAL HOSPITAL · PI TOUROUTOGLOU, ALEXANDRA · 2019 to 2023
$871k
Shared Pathophysiology of Postoperative Delirium and Alzheimer’s Disease and Related DementiasK01AG057836 · NIA · BETH ISRAEL DEACONESS MEDICAL CENTER · PI VASUNILASHORN, SARINNAPHA · 2018 to 2022
$565k
Genetic and Neuroinflammatory Mechanisms of Delirium and Alzheimer’s Disease and Related DementiasR03AG061582 · NIA · BETH ISRAEL DEACONESS MEDICAL CENTER · PI VASUNILASHORN, SARINNAPHA · 2019 to 2020
Delirium is a common postoperative complication among older patients with many adverse outcomes. Due to a lack of validated biomarkers, prediction and monitoring of delirium by biological testing is not currently feasible. Circulating proteins in cerebrospinal fluid (CSF) may reflect biological processes causing delirium. Our goal was to discover and investigate candidate protein biomarkers in preoperative CSF that were associated with the development of postoperative delirium in older surgical patients. We employed a nested case-control study design coupled with high multiplex affinity proteomics analysis to measure 1305 proteins in preoperative CSF. Twenty-four matched delirium cases and non-delirium controls were selected from the Healthier Postoperative Recovery (HiPOR) cohort, and the associations between preoperative protein levels and postoperative delirium were assessed using
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Aptamer-Based Proteomics Measuring Preoperative Cerebrospinal Fluid Protein Alterations Associated with Postoperative Delirium. · full record | OpenQuestion