Evidence map›Paper›PMID 37759785›Full record

ArticleBiomolecules2023

ROS-Mediated Fragmentation Alters the Effects of Hyaluronan on Corneal Epithelial Wound Healing.

Xiao Lin, Isabel Y Moreno, Lawrence Nguyen, Tarsis F Gesteira, Vivien J Coulson-Thomas

Open access · goldAbstract read
In one paragraph

Article in Biomolecules, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
3.4field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Engineered Tandem Thymosin Peptide Promotes Corneal Wound Healing.Investigative ophthalmology & visual science · 2025
    Article
  6. Article
  7. Polynucleotide HPTAntioxidants (Basel, Switzerland) · 2025
    Article
  8. Article
  9. Article
  10. Article
  11. Age related changes in hyaluronan expression leads to Meibomian gland dysfunction.Matrix biology : journal of the International Society for Matrix Biology · 2023
    Article
  12. In Utero Extrahepatic Bile Duct Damage and Repair: Implications for Biliary Atresia.Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Xiao LinCollege of Optometry, University of Houston, 4401 Martin Luther King Boulevard, Houston, TX 77204-2020, USA.ORCID 0000-0002-5867-6455
Isabel Y MorenoCollege of Optometry, University of Houston, 4401 Martin Luther King Boulevard, Houston, TX 77204-2020, USA.ORCID 0000-0002-4640-4364
Lawrence NguyenCollege of Optometry, University of Houston, 4401 Martin Luther King Boulevard, Houston, TX 77204-2020, USA.
Tarsis F GesteiraCollege of Optometry, University of Houston, 4401 Martin Luther King Boulevard, Houston, TX 77204-2020, USA.
Vivien J Coulson-ThomasCollege of Optometry, University of Houston, 4401 Martin Luther King Boulevard, Houston, TX 77204-2020, USA.
University of Houston · US

Funding

Research Programming ModuleP30EY007551 · NEI · UNIVERSITY OF HOUSTON · PI LAURA J. FRISHMAN · 1988 to 2026
$16.4M
VERSICAN PROTEOLYSIS AND REGULATION OF VASCULAR SMOOTH MUSCLEP01HL107147 · NHLBI · CLEVELAND CLINIC LERNER COM-CWRU · PI HASCALL, VINCENT CHARLES · 2011 to 2017
$16.1M
Hyaluronan in the limbal stem cell niche: from regulation of stem cell fate to translational applicationsR01EY029289 · NEI · UNIVERSITY OF HOUSTON · PI Vivien Jane Coulson-Thomas · 2018 to 2026
$3.0M
Modifying the extracellular matrix to prevent dry eye disease and age-related Meibomian gland dysfunction (ARMGD)R01EY033024 · NEI · UNIVERSITY OF HOUSTON · PI COULSON-THOMAS, VIVIEN JANE · 2022 to 2025
$1.6M
NEI NIH HHS P30 EY007551NEI NIH HHS R01 EY029289NEI NIH HHS R01 EY033024NHLBI NIH HHS P01 HL107147
6 · The paper itself

Abstract

A buildup of reactive oxygen species (ROS) occurs in virtually all pathological conditions. Hyaluronan (HA) is a major extracellular matrix component and is susceptible to oxidation by reactive oxygen species (ROS), yet the precise chemical structures of oxidized HA products (oxHA) and their physiological properties remain largely unknown. This study characterized the molecular weight (MW), structures, and physiological properties of oxHA. For this, high-molecular-weight HA (HMWHA) was oxidized using increasing molar ratios of hydrogen peroxide (H

Indexed as

Hyaluronic AcidHydrogen PeroxideCorneaHumansReactive Oxygen SpeciesWound HealingHyaluronic AcidHydrogen PeroxideReactive Oxygen Speciescorneal epitheliumhigh-molecular-weight hyaluronanlow-molecular-weight hyaluronanoxidative stresswound healing

Identifiers

PMID37759785
PMCPMC10526416
OpenAlexW4386712377

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.