Evidence map›Paper›PMID 37759723›Full record

Observational studyBiomolecules2023

Low Valine Serum Levels Predict Increased 1-Year Mortality in Acute Heart Failure Patients.

Iva Klobučar, Luka Vidović, Ilona Arih, Margarete Lechleitner, Gudrun Pregartner, Andrea Berghold, Hansjörg Habisch, Tobias Madl, Saša Frank, Vesna Degoricija

Open access · goldAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Biomolecules, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
0.9field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 4 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Iva KlobučarDepartment of Cardiology, Sisters of Charity University Hospital Centre, 10000 Zagreb, Croatia.ORCID 0000-0002-0640-7149
Luka VidovićDepartment of Medicine, Sisters of Charity University Hospital Centre, 10000 Zagreb, Croatia.
Ilona ArihSchool of Medicine, University of Zagreb, 10000 Zagreb, Croatia.
Margarete LechleitnerGottfried Schatz Research Center, Molecular Biology and Biochemistry, Medical University of Graz, 8010 Graz, Austria.
Gudrun PregartnerInstitute for Medical Informatics, Statistics and Documentation, Medical University of Graz, 8036 Graz, Austria.
Andrea BergholdInstitute for Medical Informatics, Statistics and Documentation, Medical University of Graz, 8036 Graz, Austria.ORCID 0000-0001-5187-9105
Hansjörg HabischGottfried Schatz Research Center, Molecular Biology and Biochemistry, Medical University of Graz, 8010 Graz, Austria.ORCID 0000-0001-5537-506X
Tobias MadlGottfried Schatz Research Center, Molecular Biology and Biochemistry, Medical University of Graz, 8010 Graz, Austria.ORCID 0000-0002-9725-5231
Saša FrankGottfried Schatz Research Center, Molecular Biology and Biochemistry, Medical University of Graz, 8010 Graz, Austria.
Vesna DegoricijaDepartment of Medicine, Sisters of Charity University Hospital Centre, 10000 Zagreb, Croatia.
Medical University of Graz · ATSisters of Charity Hospital · HRUniversity of Zagreb · HR

Funding

Austrian Research Promotion Agency 864690 and 870454Austrian Science Fund FWF I 3792Austrian Science Fund FWF P 27166Austrian Science Fund FWF P 28854Austrian Science Fund FWF W 1226FWF Austrian Science Fund P27166-B23FWF Austrian Science Fund P28854, I3792, DOC-130, DK-MCD W1226
6 · The paper itself

Abstract

Considering the relationship between disease severity and the extent of metabolic derangement in heart failure, we hypothesized that the serum levels of metabolites may have prognostic value for 1-year mortality in acute heart failure (AHF). The AHF study was a prospective, observational study enrolling consecutive patients hospitalized due to AHF. Metabolites were measured in serum collected at admission using NMR spectroscopy. Out of 315 AHF patients, 118 (37.5%) died within 1 year after hospitalization for AHF. The serum levels of 8 out of 49 identified metabolites were significantly different between patients who were alive and those who died within 1 year after hospitalization for AHF. Of these, only valine was significantly associated with 1-year mortality (hazard ratio 0.73 per 1 standard deviation increase, 95% confidence interval: 0.59-0.90,

Indexed as

Heart FailureValineAcute DiseaseAgedAged, 80 and overBiomarkersFemaleHumansKaplan-Meier EstimateMaleMiddle AgedPrognosisProspective StudiesROC CurveBiomarkersValineacute heart failuremetabolomicsmortalityNMR spectroscopyprognostic biomarkersriskvaline

Identifiers

PMID37759723
PMCPMC10527293
OpenAlexW4386255979

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.