Evidence map›Paper›PMID 37759637›Full record

ArticleBiology2023

Phenotypic Characterization of Female Carrier Mice Heterozygous for Tafazzin Deletion.

Michelle V Tomczewski, John Z Chan, Duaa M Al-Majmaie, Ming Rong Liu, Alex D Cocco, Ken D Stark, Douglas Strathdee, Robin E Duncan

Open access · goldAbstract read
In one paragraph

Article in Biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Effects of Cannabidiol on TAFAZZIN-Deficient B-Lymphoblastoid Cells.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Michelle V TomczewskiDepartment of Kinesiology and Health Sciences, Faculty of Health, University of Waterloo, 200 University Ave W., BMH1044, Waterloo, ON N2L 3G1, Canada.ORCID 0000-0002-0917-6817
John Z ChanDepartment of Kinesiology and Health Sciences, Faculty of Health, University of Waterloo, 200 University Ave W., BMH1044, Waterloo, ON N2L 3G1, Canada.ORCID 0000-0001-5964-8053
Duaa M Al-MajmaieDepartment of Kinesiology and Health Sciences, Faculty of Health, University of Waterloo, 200 University Ave W., BMH1044, Waterloo, ON N2L 3G1, Canada.
Ming Rong LiuDepartment of Kinesiology and Health Sciences, Faculty of Health, University of Waterloo, 200 University Ave W., BMH1044, Waterloo, ON N2L 3G1, Canada.
Alex D CoccoDepartment of Kinesiology and Health Sciences, Faculty of Health, University of Waterloo, 200 University Ave W., BMH1044, Waterloo, ON N2L 3G1, Canada.
Ken D StarkDepartment of Kinesiology and Health Sciences, Faculty of Health, University of Waterloo, 200 University Ave W., BMH1044, Waterloo, ON N2L 3G1, Canada.
Douglas StrathdeeTransgenic Technology Laboratory, Cancer Research UK Beatson Institute, Switchback Road, Glasgow G61 1BD, Scotland, UK.
Robin E DuncanDepartment of Kinesiology and Health Sciences, Faculty of Health, University of Waterloo, 200 University Ave W., BMH1044, Waterloo, ON N2L 3G1, Canada.ORCID 0000-0002-3926-2740
University of Waterloo · CACancer Research UK Scotland Institute · GB

Funding

Barth Syndrome Foundation Idea Grant 2015Barth Syndrome Foundation Idea Grant 2019Canada Foundation for Innovation Project No. 30259Cancer Research UK SICR_CORE_TRANST_2324Government of Ontario Early Researcher Award (ERA) ER16-12-162Government of Ontario Project No. 30259The Natural Sciences and Engineering Research Council of Canada (NSERC) RGPAS-2019-00008The Natural Sciences and Engineering Research Council of Canada (NSERC) RGPIN-2012-418213The Natural Sciences and Engineering Research Council of Canada (NSERC) RGPIN-2019-05642
6 · The paper itself

Abstract

Barth syndrome (BTHS) is caused by mutations in tafazzin resulting in deficits in cardiolipin remodeling that alter major metabolic processes. The tafazzin gene is encoded on the X chromosome, and therefore BTHS primarily affects males. Female carriers are typically considered asymptomatic, but age-related changes have been reported in female carriers of other X-linked disorders. Therefore, we examined the phenotype of female mice heterozygous for deletion of the tafazzin gene (

Indexed as

Barth syndromecardiolipincarriersenergy metabolismexercise capacityheterozygousmicemitochondriatafazzinX-linked diseases

Identifiers

PMID37759637
PMCPMC10525480
OpenAlexW4386780193

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.