Evidence map›Paper›PMID 37759546›Full record

ReviewCells2023

Regulatory Mechanisms That Guide the Fetal to Postnatal Transition of Cardiomyocytes.

Patrick G Burgon, Jonathan J Weldrick, Omar Mohamed Sayed Ahmed Talab, Muhammad Nadeer, Michail Nomikos, Lynn A Megeney

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Cells, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Patrick G BurgonDepartment of Chemistry and Earth Sciences, College of Arts and Sciences, Qatar University, Doha P.O. Box 2713, Qatar.ORCID 0000-0003-4771-023X
Jonathan J WeldrickDepartment of Medicine, Department of Cellular and Molecular Medicine, Faculty of Medicine, University of Ottawa, Ottawa, ON K1H 8M5, Canada.
Omar Mohamed Sayed Ahmed TalabCollege of Medicine, QU Health, Qatar University, Doha P.O. Box 2713, Qatar.
Muhammad NadeerCollege of Medicine, QU Health, Qatar University, Doha P.O. Box 2713, Qatar.ORCID 0000-0002-1385-5302
Michail NomikosCollege of Medicine, QU Health, Qatar University, Doha P.O. Box 2713, Qatar.
Lynn A MegeneyDepartment of Medicine, Department of Cellular and Molecular Medicine, Faculty of Medicine, University of Ottawa, Ottawa, ON K1H 8M5, Canada.

Funding

CIHR 169089
6 · The paper itself

Abstract

Heart disease remains a global leading cause of death and disability, necessitating a comprehensive understanding of the heart's development, repair, and dysfunction. This review surveys recent discoveries that explore the developmental transition of proliferative fetal cardiomyocytes into hypertrophic postnatal cardiomyocytes, a process yet to be well-defined. This transition is key to the heart's growth and has promising therapeutic potential, particularly for congenital or acquired heart damage, such as myocardial infarctions. Although significant progress has been made, much work is needed to unravel the complex interplay of signaling pathways that regulate cardiomyocyte proliferation and hypertrophy. This review provides a detailed perspective for future research directions aimed at the potential therapeutic harnessing of the perinatal heart transitions.

Indexed as

Myocardial InfarctionMyocytes, CardiacHumansSignal Transductionfetal to postnatal developmenthypertrophy and proliferationmicro-RNAsignaling pathways (mTOR, Hippo, YAP/TAZ)therapeutic potential

Identifiers

PMID37759546
PMCPMC10528641

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.