Evidence map›Paper›PMID 37759534›Full record

ArticleCells2023

Kuang-Chen Hung, Ni Tien, Da-Tian Bau, Chun-Hsu Yao, Chan-Hung Chen, Jiun-Long Yang, Meng-Liang Lin, Shih-Shun Chen

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.0field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Kuang-Chen HungDivision of Neurosurgery, Department of Surgery, Taichung Army Force General Hospital, Taichung 41152, Taiwan.ORCID 0000-0002-1560-7206
Ni TienDepartment of Laboratory Medicine, China Medical University Hospital, Taichung 404394, Taiwan.
Da-Tian BauGraduate Institute of Biomedical Sciences, China Medical University, Taichung 404333, Taiwan.ORCID 0000-0002-5504-8656
Chun-Hsu YaoDepartment of Biomedical Imaging and Radiological Science, China Medical University, Taichung 404333, Taiwan.ORCID 0000-0002-0815-2303
Chan-Hung ChenDepartment of Medical Laboratory Science and Biotechnology, China Medical University, Taichung 404333, Taiwan.
Jiun-Long YangDepartment of Nursing, St. Mary's Junior College of Medicine, Nursing and Management, Yilan 26644, Taiwan.
Meng-Liang LinDepartment of Medical Laboratory Science and Biotechnology, China Medical University, Taichung 404333, Taiwan.
Shih-Shun ChenDepartment of Medical Laboratory Science and Biotechnology, College of Medical and Health Science, Asia University, Taichung 413305, Taiwan.ORCID 0000-0001-9152-929X
China Medical University · TWAsia University · TWMackay Junior College of Medicine, Nursing and Management · TWTaichung Armed Forces General Hospital · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The aberrant activation of signaling pathways contributes to cancer cells with metabolic reprogramming. Thus, targeting signaling modulators is considered a potential therapeutic strategy for cancer. Subcellular fractionation, coimmunoprecipitation, biochemical analysis, and gene manipulation experiments revealed that decreasing the interaction of kirsten rat sarcoma viral oncogene homolog (KRAS) with p110α in lipid rafts with the use of naringenin (NGN), a citrus flavonoid, causes lipid raft-associated phosphatidylinositol 3-kinase (PI3K)-GTP-ras-related C3 botulinum toxin substrate 1 (Rac1)-protein kinase B (Akt)-regulated metabolic dysfunction of glycolysis and mitochondrial oxidative phosphorylation (OXPHOS), leading to apoptosis in human nasopharyngeal carcinoma (NPC) cells. The use of

Indexed as

Energy MetabolismMicroRNAsPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktProto-Oncogene Proteins p21(ras)rac1 GTP-Binding ProteinUp-RegulationApoptosisCell Line, TumorGene Expression Regulation, NeoplasticGlycolysisHumansMitochondriaOxidative PhosphorylationSignal TransductionKRAS protein, humanMicroRNAsmirnlet7 microRNA, humanPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktProto-Oncogene Proteins p21(ras)rac1 GTP-Binding ProteinRAC1 protein, humanbioenergetic metabolismKRASlet-7gMCPIP1naringenin

Identifiers

PMID37759534
PMCPMC10527334
OpenAlexW4386879261

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.