Evidence map›Paper›PMID 37759532›Full record

ArticleCells2023

Syringin Prevents 6-Hydroxydopamine Neurotoxicity by Mediating the MiR-34a/SIRT1/Beclin-1 Pathway and Activating Autophagy in SH-SY5Y Cells and the

Ru-Huei Fu, Syuan-Yu Hong, Hui-Jye Chen

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
2.4field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Syringin (Sinapyl Alcohol 4-International journal of molecular sciences · 2025
    Article
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Ru-Huei FuGraduate Institute of Biomedical Sciences, China Medical University, Taichung 40402, Taiwan.ORCID 0000-0001-9367-1759
Syuan-Yu HongGraduate Institute of Biomedical Sciences, China Medical University, Taichung 40402, Taiwan.
Hui-Jye ChenGraduate Institute of Biomedical Sciences, China Medical University, Taichung 40402, Taiwan.
China Medical University · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Defective autophagy is one of the cellular hallmarks of Parkinson's disease (PD). Therefore, a therapeutic strategy could be a modest enhancement of autophagic activity in dopamine (DA) neurons to deal with the clearance of damaged mitochondria and abnormal protein aggregates. Syringin (SRG) is a phenolic glycoside derived from the root of

Indexed as

MicroRNAsNeuroblastomaNeurotoxicity SyndromesParkinson Diseasealpha-SynucleinAnimalsAutophagyBeclin-1Caenorhabditis elegansGlucosidesHumansOxidopaminePhenylpropionatesSirtuin 1alpha-SynucleinBeclin-1GlucosidesMicroRNAsOxidopaminePhenylpropionatesSIRT1 protein, humanSirtuin 1syringin6-hydroxydopamine (6-OHDA)autophagyBeclin-1C. elegansmiR-34aParkinson’s diseaseSH-SY5Y cellsSIRT1syringinα-synuclein

Identifiers

PMID37759532
PMCPMC10527269
OpenAlexW4386895265

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.