ArticleCells2023
High-Intensity Focused Ultrasound Increases Collagen and Elastin Fiber Synthesis by Modulating Caveolin-1 in Aging Skin.
Article in Cells, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.
- Efficacy and safety of intense focused ultrasound for skin rejuvenation: a systematic review and meta-analysis.Archives of dermatological research · 2024Pooled it
- Vaginal high-intensity focused ultrasound in women with genitourinary syndrome of menopause: a prospective exploratory study.Sexual medicine · 2026Article
- Longitudinal Changes in Systemic Total Oxidant Status Following High-Intensity Focused Ultrasound for Facial Rejuvenation: A Prospective 6-Month Controlled Pilot Study.Sensors (Basel, Switzerland) · 2026Article
- Downregulation of SPRED1 drives keratinocyte hyperproliferation in psoriasis via activation of the ERK-RSK1 signaling axis.iScience · 2026Article
- Photoaging: Update on Pathogenesis, Prevention, and Treatment.Annals of dermatology · 2026Review
- Mechanically Induced Skin Renewal: Evidence-Based Insights Into Clinical, Structural and Inflammatory Changes Activated by Microneedling, Microdermabrasion and Microvibration.Journal of cosmetic dermatology · 2026Review
- Multi-tissue analysis identifies mitochondrial genes in chicken aging-induced productivity decline.Journal of animal science and biotechnology · 2026Article
- Treatment of Melasma Targeting Dermal-Epidermal Interactions Utilizing High-Intensity, High-Frequency Parallel Ultrasound Beam in Asian Skin.Journal of cosmetic dermatology · 2026Article
- Mitochondria-Targeted Biophysical Priming of Autologous Biologics for Skin Regeneration and Wound Repair.International journal of molecular sciences · 2026Review
- Use of High-Intensity Focused Ultrasound in the Periorbital Rejuvenation: A Systematic Review.Aesthetic surgery journal. Open forum · 2026Review
- Enhancing the Efficacy of Poly-l-Lactic Acid Injections With Micro-Focused Ultrasound: An Evaluation of Combined Treatment and Optimal Sequence.Journal of cosmetic dermatology · 2026Article
- High-Intensity Focused Ultrasound for Facial Rejuvenation and Body Contouring: A Bibliometric Analysis of Efficacy and Safety Studies.Aesthetic surgery journal. Open forum · 2026Review
- High-Intensity Focused Ultrasound for the Treatment of Infraorbital Fat Protrusion: A Preliminary Case Series.Clinical, cosmetic and investigational dermatology · 2026Article
- Non-Surgical Correction of Facial Asymmetry: A Narrative Review of Non-Surgical Modalities and Clinical Case Examples.Journal of clinical medicine · 2025Review
- Targeting SIRT1 via Exosomes Derived From Oleuropein-Treated Cells: A Novel Approach to Rejuvenation Skin Through miRNA Modulation.Food science & nutrition · 2025Article
- Targeting Dermal Fibroblast Senescence: From Cellular Plasticity to Anti-Aging Therapies.Biomedicines · 2025Review
- Article
- Analysis of the clinical application and treatment effects of Ultra-Pulse Shockwave technology in facial rejuvenation.Lasers in medical science · 2025Article
- Energy-Based Skin Rejuvenation: A Review of Mechanisms and Thermal Effects.Journal of cosmetic dermatology · 2025Review
- Do Different High-Intensity-Focused Ultrasound Frequencies Have Different Effects? A Histological Analysis Correlated With Patients' Subjective Assessments.Journal of cosmetic dermatology · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Caveolin-1 (Cav-1) induces cellular senescence by reducing extracellular signal-regulated kinase (ERK)1/2 phosphorylation and activating p53 via inhibition of mouse double minute 2 homolog (MDM2) and sirtuin 1 (Sirt1), promoting cell cycle arrest and decreasing fibroblast proliferation and collagen synthesis. High-intensity focused ultrasound (HIFU) treatment increases collagen synthesis, rejuvenating skin. Using H
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.