Evidence map›Paper›PMID 37759444›Full record

ArticleCells2023

Canagliflozin, an Inhibitor of the Na

Bosung Shim, Jesse A Stokum, Mitchell Moyer, Natalya Tsymbalyuk, Orest Tsymbalyuk, Kaspar Keledjian, Svetlana Ivanova, Cigdem Tosun, Volodymyr Gerzanich, J Marc Simard

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06750458 (Comparative Study Between Dapagliflozin Versus Dexamethasone Role in Pre-operative Management of Non- Diabetic Brain Tumor Patients), which is not on this map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
2.6field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06750458 phase3not yet recruitingnot on this mapstarted 2025, after this paper: background citation

Comparative Study Between Dapagliflozin Versus Dexamethasone Role in Pre-operative Management of Non- Diabetic Brain Tumor Patients

TypeinterventionalSponsorTanta UniversityRan2025 to 2026Enrolled75ConditionsGlioma, Dapagliflozin (Forxiga), DexamethasoneArmsDapagliflozin placebo, Placebo, DexamethasoneGroup III (n=25) (Dexamethasone group)
3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 13 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Sodium-glucose cotransporter 2 inhibitors and atherosclerosis.American journal of preventive cardiology · 2025
    Review
  5. A Mouse Model of Temporal Lobe Contusion.Journal of neurotrauma · 2025
    Article
  6. Article
  7. Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Bosung ShimDepartment of Neurosurgery, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Jesse A StokumDepartment of Neurosurgery, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Mitchell MoyerDepartment of Neurosurgery, University of Maryland School of Medicine, Baltimore, MD 21201, USA.ORCID 0000-0002-7504-1435
Natalya TsymbalyukDepartment of Neurosurgery, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Orest TsymbalyukDepartment of Neurosurgery, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Kaspar KeledjianDepartment of Neurosurgery, University of Maryland School of Medicine, Baltimore, MD 21201, USA.ORCID 0009-0008-5097-1944
Svetlana IvanovaDepartment of Neurosurgery, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Cigdem TosunDepartment of Neurosurgery, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Volodymyr GerzanichDepartment of Neurosurgery, University of Maryland School of Medicine, Baltimore, MD 21201, USA.ORCID 0000-0002-6714-1946
J Marc SimardDepartment of Neurosurgery, University of Maryland School of Medicine, Baltimore, MD 21201, USA.ORCID 0000-0002-5373-1988
University of Maryland, Baltimore · US

Funding

Aquaporin-4 regulation by NCX1 in post-ischemic brain swellingR01NS127986 · NINDS · UNIVERSITY OF MARYLAND BALTIMORE · PI J. Marc Simard · 2022 to 2026
$1.9M
Advanced components for an existing spinning disk confocal in an established core imaging facilityS10OD026698 · OD · UNIVERSITY OF MARYLAND BALTIMORE · PI BLANPIED, THOMAS A · 2019 to 2019
$274k
NIH HHS S10 OD026698NINDS NIH HHS R01 NS127986
6 · The paper itself

Abstract

Brain swelling is a major cause of death and disability in ischemic stroke. Drugs of the gliflozin class, which target the Na

Indexed as

Brain EdemaBrain IschemiaDiabetes Mellitus, Type 2Ischemic StrokeSodium-Glucose Transporter 2 InhibitorsAnimalsAstrocytesCanagliflozinGlucoseInfarctionIonsMiceSodium-Glucose Transporter 2CanagliflozinGlucoseIonsSodium-Glucose Transporter 2Sodium-Glucose Transporter 2 Inhibitorsastrocytebrain swellingcanagliflozincerebral ischemiadiabetesSGLT2stroke

Identifiers

PMID37759444
PMCPMC10527352
OpenAlexW4386484161

What OpenQuestion holds

Texttitle and abstract
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.