Evidence map›Paper›PMID 37759206›Full record

ArticleBMC microbiology2023

Anaplasma phagocytophilum Ats-1 enhances exosome secretion through Syntenin-1.

Ruirui Li, Zhongchen Ma, Wei Zheng, Yangyang Xiao, Zhen Wang, Jihai Yi, Yong Wang, Chuangfu Chen

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC microbiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Ruirui Li *International Research Center for Animal Health Breeding, College of Animal Science and Technology, Shihezi University, Shihezi, China.
Zhongchen Ma *International Research Center for Animal Health Breeding, College of Animal Science and Technology, Shihezi University, Shihezi, China.
Wei Zheng *International Research Center for Animal Health Breeding, College of Animal Science and Technology, Shihezi University, Shihezi, China.
Yangyang XiaoInternational Research Center for Animal Health Breeding, College of Animal Science and Technology, Shihezi University, Shihezi, China.
Zhen WangInternational Research Center for Animal Health Breeding, College of Animal Science and Technology, Shihezi University, Shihezi, China.
Jihai YiInternational Research Center for Animal Health Breeding, College of Animal Science and Technology, Shihezi University, Shihezi, China.
Yong WangInternational Research Center for Animal Health Breeding, College of Animal Science and Technology, Shihezi University, Shihezi, China. yongwang@shzu.edu.cn.
Chuangfu ChenInternational Research Center for Animal Health Breeding, College of Animal Science and Technology, Shihezi University, Shihezi, China. chuangfu_chen@163.com.
Shihezi University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Anaplasma phagocytophilum is an intracellular obligate parasite that causes granulocytic anaplasmosis. Effector Ats-1 is an important virulence factor of A. phagocytophilum. Multiomics screening and validation has been used to determine that Ats-1 regulates host cell apoptosis and energy metabolism through the respiratory chain mPTP axis. In this study, a total of 19 potential binding proteins of Ats-1 in host cells were preliminarily screened using a yeast two-hybrid assay, and the interaction between syntenin-1 (SDCBP) and Ats-1 was identified through immunoprecipitation. Bioinformatics analysis showed that SDCBP interacted with SDC1, SDC2, and SDC4 and participated in the host exosome secretion pathway. Further studies confirmed that Ats-1 induced the expression of SDC1, SDC2, and SDC4 in HEK293T cells through SDCBP and increased the exosome secretion of these cells. This indicated that SDCBP played an important role in Ats-1 regulating the exosome secretion of the host cells. These findings expand our understanding of the intracellular regulatory mechanism of A. phagocytophilum, which may enhance its own infection and proliferation by regulating host exosome pathways.

Indexed as

Anaplasma phagocytophilumAnaplasmosisExosomesAnimalsHEK293 CellsHumansSynteninsSDCBP protein, humanSynteninsA. phagocytophilumEffector protein Ats-1ExosomeSyntenin-1 (SDCBP)

Identifiers

PMID37759206
PMCPMC10523776
OpenAlexW4387100774

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.