ArticleAdvances in therapy2023
Economic Evaluation of a Bioinductive Implant for the Repair of Rotator Cuff Tears Compared with Standard Surgery in Italy.
Article in Advances in therapy, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The bioinductive collagen implant yields positive histological, clinical and MRI outcomes in the management of rotator cuff tears: A systematic review.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2025Pooled it
- Article
- The substantial economic burden of rotator cuff pathology: A nationwide cost-of-illness study.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2026Article
- A novel all-arthroscopic technique for biomaterials insertion and positioning on shoulder rotator cuff: Preliminary insights and experience on a cohort of 34 patients.Journal of experimental orthopaedics · 2026Article
- Acellular dermal matrix alone or in combination with subacromial bursa and humeral bone marrow concentrate for augmentation of massive rotator cuff tear repair: a double-blind randomized controlled trial protocol (MODA).Frontiers in medicine · 2026Article
- The role of new synthetic membranes in rotator cuff augmentation.Journal of experimental orthopaedics · 2026Review
- Arthroscopic Bioinductive Collagen Scaffold Augmentation in High-Risk Posterosuperior Rotator Cuff Tears: Clinical and Radiological Outcomes.Journal of clinical medicine · 2025Article
- Loose Body Formation in the Subacromial Bursa following Rotator Cuff Repair with a REGENETEN® Bioinductive Implant: A Case Report.Journal of orthopaedic case reports · 2025Article
- Augmentation of full-thickness rotator cuff tears with a bioinductive collagen implant does not reduce retear rates - a propensity matched cohort study.BMC musculoskeletal disorders · 2025Article
- Partial-Thickness Bursal-Site Rotator Cuff Repair With Autologous Bursa Augmentation.Arthroscopy techniques · 2025Article
- Commercial Biomaterial-Based Products for Tendon Surgical Augmentation: A Scoping Review on Currently Available Medical Devices.Journal of functional biomaterials · 2025Review
- Adoption of a Societal Perspective in Economic Evaluations of Musculoskeletal Disorders: A Conceptual Paper.Journal of market access & health policy · 2024Article
- Patch Augmentation in Arthroscopic Rotator Cuff Surgery-Review of Current Evidence and Newest Trends.Journal of clinical medicine · 2024Review
- Biologic Augmentation Improves Rotator Cuff Integrity But Not Clinically Significant Patient Outcomes: A Meta-Analysis of Randomized Controlled Trials.JB & JS open accessReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionRotator cuff tear (RCT) is a painful, progressive condition resulting from damage to the rotator cuff tendons and is the leading cause of shoulder-related disability. Surgical repair of rotator cuff is an established standard of care (SOC); however, failure of the procedure can occur. In this context, the use of collagen-based bioinductive implant REGENETEN showed long-term improvements in clinical scores. The aim of the study was to assess the cost-effectiveness of REGENETEN combined with SOC (SOC + REGENETEN) compared to SOC alone from both National Healthcare Service (NHS) and societal perspectives in Italy.
methodsA decision analytic model was developed to estimate the number of tears healed and costs for the two considered treatment strategies over 1 year. Clinical data were retrieved from the literature, and the clinical pathways for the management of patients with RCTs were retrieved from four key opinion leaders in Italy.
resultsOver a 1-year time horizon, healed lesions were 90.70% and 72.90% for surgical repair of RCTs with and without REGENETEN, respectively. Considering the NHS perspective, mean costs per patient were €7828 and €4650 for the two strategies, respectively, leading to an incremental cost-effectiveness ratio (ICER) of €17,857 per healed tear. From the societal perspective, the mean costs per patient were €12,659 for SOC and €11,784 for REGENETEN, thus showing savings of €4918 per healed tear when the bioinductive implant is used. The sensitivity analyses confirmed the robustness of the model results.
conclusionIn the context of paucity of cost-effectiveness studies, our findings provide additional evidence for clinicians and payers regarding the value of a new treatment option that supports a tailored approach for the management of patients with RCTs.
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