Evidence map›Paper›PMID 37758954›Full record

ArticleNature2023

Transposon-encoded nucleases use guide RNAs to promote their selfish spread.

Chance Meers, Hoang C Le, Sanjana R Pesari, Florian T Hoffmann, Matt W G Walker, Jeanine Gezelle, Stephen Tang, Samuel H Sternberg

Open access · greenAbstract read
In one paragraph

Article in Nature, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed
8.8field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 57 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Structural visualization of the molecular evolution of CRISPR-Cas9.Nature structural & molecular biology · 2026
    Article
  11. Stepwise DNA unwinding gates TnpB genome-editing activity.bioRxiv : the preprint server for biology · 2026
    Article
  12. Article
  13. Review
  14. Mutational scanning of TnpB reveals latent activity for genome editing.bioRxiv : the preprint server for biology · 2025
    Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Chance MeersDepartment of Biochemistry and Molecular Biophysics, Columbia University, New York, NY, USA.ORCID 0000-0003-2554-3987
Hoang C LeDepartment of Biology, University of Pennsylvania, Philadelphia, PA, USA.
Sanjana R PesariDepartment of Biochemistry and Molecular Biophysics, Columbia University, New York, NY, USA.
Florian T HoffmannDepartment of Biochemistry and Molecular Biophysics, Columbia University, New York, NY, USA.ORCID 0000-0003-0301-4259
Matt W G WalkerDepartment of Biological Sciences, Columbia University, New York, NY, USA.ORCID 0000-0003-3345-8248
Jeanine GezelleDepartment of Biochemistry and Molecular Biophysics, Columbia University, New York, NY, USA.ORCID 0000-0003-3664-6199
Stephen TangDepartment of Biochemistry and Molecular Biophysics, Columbia University, New York, NY, USA.ORCID 0000-0001-5492-9796
Samuel H SternbergDepartment of Biochemistry and Molecular Biophysics, Columbia University, New York, NY, USA. shsternberg@gmail.com.ORCID 0000-0001-8240-9114
Columbia University · USUniversity of California San Diego · US

Funding

Center for Genomic Editing and Recording: Development and Application of Next-Generation Genome and Epigenome Editing Methods to Advance the Study and Treatment of Human DiseaseRM1HG009490 · NHGRI · WHITEHEAD INSTITUTE FOR BIOMEDICAL RES · PI Brittany S. Adamson, Martin Joseph Ankrah Aryee · 2017 to 2026
$22.7M
Medical Scientist Training ProgramT32GM145440 · NIGMS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI STEVEN L REINER · 2022 to 2026
$7.3M
Leveraging Programmable Integrases for Human Genome EngineeringDP2HG011650 · NHGRI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI STERNBERG, SAMUEL HENRY · 2020 to 2020
$2.4M
Uncovering the molecular function of novel transposon-encoded Cas9 homologsF32GM143924 · NIGMS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MEERS, CHANCE · 2022 to 2023
$139k
NHGRI NIH HHS DP2 HG011650NHGRI NIH HHS RM1 HG009490NIGMS NIH HHS F32 GM143924NIGMS NIH HHS T32 GM145440
6 · The paper itself

Abstract

Insertion sequences are compact and pervasive transposable elements found in bacteria, which encode only the genes necessary for their mobilization and maintenance

Indexed as

DNA Transposable ElementsEndonucleasesGeobacillus stearothermophilusRNATransposasesBacterial ProteinsCRISPR-Cas SystemsDNA CleavageEvolution, MolecularBacterial ProteinsDNA Transposable ElementsEndonucleasesRNATransposases

Identifiers

PMID37758954
PMCPMC11758364
OpenAlexW4387095549

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.