Evidence map›Paper›PMID 37758945›Full record

ArticleNature2023

A bioelectrical phase transition patterns the first vertebrate heartbeats.

Bill Z Jia, Yitong Qi, J David Wong-Campos, Sean G Megason, Adam E Cohen

Abstract read
PubMed Publisher
In one paragraph

Article in Nature, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed.

  1. Immature and mature myocardium in the pathophysiology of hypertrophic cardiomyopathy.Journal of molecular and cellular cardiology plus · 2026
    Review
  2. Heart rate control by listening to light.Nature communications · 2026
    Article
  3. Article
  4. Article
  5. Absolute voltage mapping using dynamic photocycle control.bioRxiv : the preprint server for biology · 2026
    Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Coordination of cardiogenesis in vivo and in vitro.Nature reviews. Molecular cell biology · 2026
    Review
  11. Swimming motions evoke Piezo1-dependent CaCurrent biology : CB · 2025
    Article
  12. Article
  13. Article
  14. Custom 3D-Printed Molds for Zebrafish Imaging and Cardiac Development.Journal of visualized experiments : JoVE · 2025
    Article
  15. Article
  16. Aging and sinus node dysfunction: mechanisms and future directions.Clinical science (London, England : 1979) · 2025
    Review
  17. Article
  18. Review
  19. Optogenetic control of Nodal signaling patterns.Development (Cambridge, England) · 2025
    Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Bill Z JiaDepartment of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA.ORCID 0000-0002-1138-3217
Yitong QiDepartment of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA.
J David Wong-CamposDepartment of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA.
Sean G MegasonDepartment of Systems Biology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA. megason@hms.harvard.edu.ORCID 0000-0002-9330-2934
Adam E CohenDepartment of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA. cohen@chemistry.harvard.edu.ORCID 0000-0002-8699-2404

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A regular heartbeat is essential to vertebrate life. In the mature heart, this function is driven by an anatomically localized pacemaker. By contrast, pacemaking capability is broadly distributed in the early embryonic heart

Indexed as

Embryonic DevelopmentHeartHeart RateZebrafishAction PotentialsAnimalsCalcium Channels, L-TypeElectrophysiologySingle-Cell AnalysisCalcium Channels, L-TypeL-type calcium channel alpha(1C)

Identifiers

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.