Evidence map›Paper›PMID 37758944›Full record

ArticleNature2023

Assembloid CRISPR screens reveal impact of disease genes in human neurodevelopment.

Xiangling Meng, David Yao, Kent Imaizumi, Xiaoyu Chen, Kevin W Kelley, Noah Reis, Mayuri Vijay Thete, Arpana Arjun McKinney, Shravanti Kulkarni, Georgia Panagiotakos and 2 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 87 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
87citing papers in PubMed, 1 pooled it
17.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

87 citing papers in PubMed, 1 synthesis or guideline pooled it, 116 citations in OpenAlex.

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27 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Xiangling MengDepartment of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, USA.ORCID http://orcid.org/0000-0002-3528-4037
David YaoDepartment of Genetics, Stanford University, Stanford, CA, USA.
Kent ImaizumiDepartment of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, USA.ORCID http://orcid.org/0000-0002-3565-5248
Xiaoyu ChenDepartment of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, USA.
Kevin W KelleyDepartment of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, USA.
Noah ReisDepartment of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, USA.ORCID http://orcid.org/0000-0002-7258-2463
Mayuri Vijay TheteDepartment of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, USA.
Arpana Arjun McKinneyEli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, CA, USA.
Shravanti KulkarniDepartment of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, USA.
Georgia PanagiotakosEli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, CA, USA.
Michael C BassikDepartment of Genetics, Stanford University, Stanford, CA, USA.ORCID http://orcid.org/0000-0001-5185-8427
Sergiu P PașcaDepartment of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, USA. spasca@stanford.edu.ORCID http://orcid.org/0000-0002-3216-3248
Neurosciences Institute · USAllen Institute for Brain Science · USStanford University · US

Funding

Four Laser, 18 Color Cell Sorter in the SSFFS10RR025518 · NCRR · STANFORD UNIVERSITY · PI HERZENBERG, LEONARD A · 2009 to 2009
$500k
NCRR NIH HHS S10 RR025518
6 · The paper itself

Abstract

The assembly of cortical circuits involves the generation and migration of interneurons from the ventral to the dorsal forebrain

Indexed as

CRISPR-Cas SystemsGene EditingNeurodevelopmental DisordersActive Transport, Cell NucleusCell MovementDNA-Binding ProteinsEndoplasmic ReticulumFemaleHumansInfant, NewbornInterneuronsMembrane ProteinsOrganoidsPregnancyProsencephalonRNA-Binding ProteinsCSDE1 protein, humanDNA-Binding ProteinsLNPK protein, humanMembrane ProteinsRNA-Binding ProteinsSmad4 ProteinSMAD4 protein, human

Identifiers

PMID37758944
PMCPMC10567561
OpenAlexW4387095486

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.