Evidence map›Paper›PMID 37758901›Full record

ArticleCommunications biology2023

Shifts in isoform usage underlie transcriptional differences in regulatory T cells in type 1 diabetes.

Jeremy R B Newman, S Alice Long, Cate Speake, Carla J Greenbaum, Karen Cerosaletti, Stephen S Rich, Suna Onengut-Gumuscu, Lauren M McIntyre, Jane H Buckner, Patrick Concannon

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Communications biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.9field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Jeremy R B NewmanDepartment of Pathology, Immunology and Laboratory Medicine, College of Medicine, University of Florida, Gainesville, FL, 32601, USA.
S Alice LongCenter for Translational Immunology, Benaroya Research Institute at Virginia Mason, Seattle, WA, 98101, USA.ORCID http://orcid.org/0000-0002-0281-1240
Cate SpeakeCenter for Interventional Immunology, Benaroya Research Institute at Virginia Mason, Seattle, WA, 98101, USA.ORCID http://orcid.org/0000-0003-1480-4272
Carla J GreenbaumCenter for Interventional Immunology, Benaroya Research Institute at Virginia Mason, Seattle, WA, 98101, USA.ORCID http://orcid.org/0000-0003-4451-9800
Karen CerosalettiCenter for Translational Immunology, Benaroya Research Institute at Virginia Mason, Seattle, WA, 98101, USA.
Stephen S RichCenter for Public Health Genomics, University of Virginia, Charlottesville, VA, 22908, USA.ORCID http://orcid.org/0000-0003-3872-7793
Suna Onengut-GumuscuCenter for Public Health Genomics, University of Virginia, Charlottesville, VA, 22908, USA.ORCID http://orcid.org/0000-0002-6563-8334
Lauren M McIntyreUniversity of Florida Genetics Institute, University of Florida, Gainesville, FL, 32601, USA.ORCID http://orcid.org/0000-0002-0077-3359
Jane H BucknerCenter for Translational Immunology, Benaroya Research Institute at Virginia Mason, Seattle, WA, 98101, USA.ORCID http://orcid.org/0000-0002-9005-1885
Patrick ConcannonDepartment of Pathology, Immunology and Laboratory Medicine, College of Medicine, University of Florida, Gainesville, FL, 32601, USA. patcon@ufl.edu.
Virginia Mason Medical Center · USUniversity of Florida · USUniversity of Virginia · US

Funding

Project 3P01AI042288 · NIAID · UNIVERSITY OF FLORIDA · PI Todd Michael Brusko · 1997 to 2026
$32.9M
Expression and proteomic characterization of risk loci in type 1 diabetesDP3DK085678 · NIDDK · UNIVERSITY OF VIRGINIA · PI RICH, STEPHEN S. · 2009 to 2009
$6.6M
Defining mechanisms of CD8 T cell exhaustion in T1DR01AI141952 · NIAID · BENAROYA RESEARCH INST AT VIRGINIA MASON · PI LONG, S ALICE · 2020 to 2024
$2.8M
Critical role for alternative splicing in conferring risk for type 1 diabetesR01DK116954 · NIDDK · UNIVERSITY OF FLORIDA · PI CONCANNON, PATRICK · 2018 to 2021
$2.0M
Novel T1D risk variants from genomic analyses in high risk familiesR01DK106718 · NIDDK · UNIVERSITY OF FLORIDA · PI CONCANNON, PATRICK · 2015 to 2018
$1.4M
NIAID NIH HHS P01 AI042288NIDDK NIH HHS DP3 DK085678NIDDK NIH HHS R01 DK106718NIDDK NIH HHS R01 DK116954
6 · The paper itself

Abstract

Genome-wide association studies have identified numerous loci with allelic associations to Type 1 Diabetes (T1D) risk. Most disease-associated variants are enriched in regulatory sequences active in lymphoid cell types, suggesting that lymphocyte gene expression is altered in T1D. Here we assay gene expression between T1D cases and healthy controls in two autoimmunity-relevant lymphocyte cell types, memory CD4

Indexed as

Diabetes Mellitus, Type 1T-Lymphocytes, RegulatoryAlternative SplicingGenome-Wide Association StudyHumansProtein IsoformsProtein Isoforms

Identifiers

PMID37758901
PMCPMC10533491
OpenAlexW4387099283

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.