ArticleNature communications2023
A phylogenetically-conserved axis of thalamocortical connectivity in the human brain.
Article in Nature communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 32 citations in OpenAlex.
- Multiscale brain development across the human lifespan.Communications biology · 2026Review
- Conserved and specialized features of thalamocortical wiring revealed by single-cell projection mapping in mouse and marmoset.bioRxiv : the preprint server for biology · 2026Article
- Developmental human brain connectome from fetal stage to early childhood.Developmental cognitive neuroscience · 2026Review
- Two gradients, one cortex.National science review · 2026Article
- TransBrain: a computational framework for translating brain-wide phenotypes between humans and mice.Nature methods · 2026Article
- Constructing the human brain metabolic connectome with MR spectroscopic imaging reveals cerebral biochemical organization.Nature communications · 2025Article
- Article
- Genetic and striatal structural connection linking behavioral inhibition/activation system to adolescent anxiety and depression.Translational psychiatry · 2025Article
- Article
- Geometric constraints on the architecture of mammalian cortical connectomes.bioRxiv : the preprint server for biology · 2025Article
- A Preliminary Study on the Accuracy of MRI-Guided Thalamic Infusion of AAV2-GFP and Biodistribution Analysis Using Cryo-Fluorescence Tomography in Nonhuman Primates.Pharmaceutics · 2025Article
- The spatial extent of anatomical connections within the thalamus varies across the cortical hierarchy in humans and macaques.bioRxiv : the preprint server for biology · 2025Article
- A multimodal characterization of low-dimensional thalamocortical structural connectivity patterns.Communications biology · 2025Article
- Perinatal development of structural thalamocortical connectivity.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Coming up short: Generative network models fail to accurately capture long-range connectivity.Network neuroscience (Cambridge, Mass.) · 2025Article
- A conserved cell-type gradient across the human mediodorsal and paraventricular thalamus.bioRxiv : the preprint server for biology · 2024Article
- A shifting role of thalamocortical connectivity in the emergence of cortical functional organization.Nature neuroscience · 2024Article
- A sensorimotor-association axis of thalamocortical connection development.bioRxiv : the preprint server for biology · 2024Article
- Cortical timescales and the modular organization of structural and functional brain networks.Human brain mapping · 2024Article
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Authors and funding
2 authors at 2 institutions in 1 country.
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Abstract
The thalamus enables key sensory, motor, emotive, and cognitive processes via connections to the cortex. These projection patterns are traditionally considered to originate from discrete thalamic nuclei, however recent work showing gradients of molecular and connectivity features in the thalamus suggests the organisation of thalamocortical connections occurs along a continuous dimension. By performing a joint decomposition of densely sampled gene expression and non-invasive diffusion tractography in the adult human thalamus, we define a principal axis of genetic and connectomic variation along a medial-lateral thalamic gradient. Projections along this axis correspond to an anterior-posterior cortical pattern and are aligned with electrophysiological properties of the cortex. The medial-lateral axis demonstrates phylogenetic conservation, reflects transitions in neuronal subtypes, and shows associations with neurodevelopment and common brain disorders. This study provides evidence for a supra-nuclear axis of thalamocortical organisation characterised by a graded transition in molecular properties and anatomical connectivity.
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