ArticleNature communications2023
Time-dependent memory transformation in hippocampus and neocortex is semantic in nature.
Article in Nature communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Perceptual and conceptual influences on memory judgments.Communications psychology · 2026Article
- Neural correlates and reinstatement of recent and remote memory in children and young adults.eLife · 2025Article
- Posttraining noradrenergic stimulation maintains hippocampal engram reactivation and episodic-like specificity of remote memory.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025Article
- Hippocampal transformations occur along dimensions of memory interference.bioRxiv : the preprint server for biology · 2025Article
- The intrinsic time tracker: temporal context is embedded in entorhinal and hippocampal functional connectivity patterns.Nature communications · 2025Article
- Evolving Engrams Demand Changes in Effective Cues.Hippocampus · 2025Review
- Memory Boost for Recurring Emotional Events Is Driven by Initial Amygdala Response Promoting Stable Neocortical Patterns across Repetitions.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Time-dependent consolidation mechanisms of durable memory in spaced learning.Communications biology · 2025Article
- Neural signatures of automatic letter-speech sound integration in literate adults.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Article
- Opposing effects of pre-encoding stress on neural substrates of item and emotional contextual source memory retrieval.Neurobiology of stress · 2024Article
- Processing of social closeness in the human brain.Communications biology · 2024Article
- Consolidation Enhances Sequential Multistep Anticipation but Diminishes Access to Perceptual Features.Psychological science · 2024Article
- The Radioprotective Effect of LBP on Neurogenesis and Cognition after Acute Radiation Exposure.Current radiopharmaceuticals · 2024Article
- Time-dependent memory transformation in hippocampus and neocortex is semantic in nature.Nature communications · 2023Article
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5 authors.
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Abstract
Memories undergo a time-dependent neural reorganization, which is assumed to be accompanied by a transformation from detailed to more gist-like memory. However, the nature of this transformation and its underlying neural mechanisms are largely unknown. Here, we report that the time-dependent transformation of memory is semantic in nature, while we find no credible evidence for a perceptual transformation. Model-based MRI analyses reveal time-dependent increases in semantically transformed representations of events in prefrontal and parietal cortices, while specific pattern representations in the anterior hippocampus decline over time. Posterior hippocampal memory reinstatement, in turn, increases over time and is linked to the semantic gist of the original memory, without a statistically significant link to perceptual details. These findings indicate that qualitative changes in memory over time, associated with distinct representational changes in the neocortex and within the hippocampus, reflect a semantic transformation, which may promote the integration of memories into abstract knowledge structures.
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