Evidence map›Paper›PMID 37758669›Full record

ArticleBMJ open2023

Associations of serum uric acid with cardiovascular disease risk factors: a retrospective cohort study in southeastern China.

Yingxian Luo, Qiong Wu, Runtang Meng, Fuzhi Lian, Chen Jiang, Meiyu Hu, Yaxin Wang, Haiyan Ma

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ open, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 7 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Yingxian LuoSchool of Public Health, Hangzhou Normal University, Hangzhou, China.ORCID 0000-0002-0306-4638
Qiong WuSchool of Public Health, Hangzhou Normal University, Hangzhou, China.
Runtang MengSchool of Public Health, Hangzhou Normal University, Hangzhou, China.ORCID 0000-0002-5826-5576
Fuzhi LianSchool of Public Health, Hangzhou Normal University, Hangzhou, China.ORCID 0000-0002-0733-579X
Chen JiangSchool of Public Health, Hangzhou Normal University, Hangzhou, China.
Meiyu HuSchool of Public Health, Hangzhou Normal University, Hangzhou, China.
Yaxin WangSchool of Public Health, Hangzhou Normal University, Hangzhou, China.
Haiyan MaSchool of Public Health, Hangzhou Normal University, Hangzhou, China mahaiyan@hznu.edu.cn.
Hangzhou Normal University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo evaluate the associations between serum uric acid (SUA) levels and cardiovascular disease (CVD) risk factors, focusing on potential sex-specific differences.

designA retrospective cohort study.

settingA large community-based survey was conducted every two years from 2010 to 2018 in Hangzhou, Zhejiang Province, outheastern China.

participants6119 participants aged 40 years and above who underwent at least three times of physical examinations were enrolled.

methodsParticipants were categorised into four groups (Q1-Q4) based on baseline SUA quartiles within the normal range, with hyperuricaemia (HUA) as the fifth group. The Q1 was the reference. By stratifying participants by gender, the relationships between SUA levels and systolic blood pressure (SBP), diastolic blood pressure (DBP), fasting blood glucose (FBG) and total cholesterol (TC) were investigated using linear regression models in the generalised estimating equation. Additionally, the associations of elevated SUA levels and HUA with hypertension, hyperglycaemia and dyslipidaemia were correspondingly examined using multivariate logistic regression models.

resultsAfter adjusting for confounding variables, we found positive associations between SUA levels and SBP, DBP, FBG and TC in women, and with TC in men (p<0.01). Likewise, elevated SUA quartiles and HUA were linked to increased dyslipidaemia risk in both sexes, and increased hyperglycaemia risk only in women, with HRs (95% CI) of 1.64 (1.05 to 2.55) and 2.37 (1.47 to 3.81) in the Q4 and HUA group, respectively. Women with HUA had higher hypertension risk (HR=1.45, 95% CI 1.21 to 1.73), while no such association was observed in men. Stratified analyses revealed significant associations between elevated SUA levels and CVD risk factors in postmenopausal and non-obese women.

conclusionsElevated SUA levels increase the risk of dyslipidaemia in both sexes. SUA levels within normal range and HUA are positively associated with hyperglycaemia and hypertension in postmenopausal women, but not in men.

Indexed as

Cardiovascular DiseasesHyperglycemiaHypertensionHyperuricemiaChinaFemaleHumansMaleRetrospective StudiesUric AcidUric AcidDIABETES & ENDOCRINOLOGYFactor Analysis, StatisticalGeneral diabetesHypertensionLipid disorders

Identifiers

PMID37758669
PMCPMC10537982
OpenAlexW4387078903

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.