Evidence map›Paper›PMID 37758590›Full record

ReviewTrends in cognitive sciences2024

The cognitive (lateral) hypothalamus.

Melissa J Sharpe

Abstract readReview
In one paragraph

Review in Trends in cognitive sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Deliberating on the role of dopamine.Trends in cognitive sciences · 2025
    Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Hypothalamic Control of Learned Flight Induced by Threat Imminence.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Article
  15. Review
  16. Article
  17. Review
  18. Review
  19. Article
  20. Dopamine Release in the Nucleus Accumbens Core Encodes the General Excitatory Components of Learning.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Melissa J SharpeDepartment of Psychology, University of Sydney, Camperdown, NSW 2006, Australia; Department of Psychology, University of California, Los Angeles, Los Angeles, CA, USA. Electronic address: melissa.sharpe@sydney.edu.au.

Funding

UCLA Training Program in Translational Neuroscience of Drug Abuse (TNDA)T32DA024635 · NIDA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LARA A. RAY, Kate M Wassum · 2008 to 2026
$6.2M
Contribution of non-canonical dopamine pathways to model-based learningR01DA057084 · NIDA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Melissa Sharpe, Kate M Wassum · 2023 to 2026
$2.5M
The role of the lateral hypothalamus in the balance of learning and behavior towards relevant stimuliR01DA054967 · NIDA · UNIVERSITY OF SYDNEY · PI Melissa Sharpe · 2022 to 2026
$1.5M
Investigating the Recruitment of Lateral Hypothalamic Circuits for Encoding Fear Memories Following Experience with Reward LearningR21MH126278 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SHARPE, MELISSA · 2022 to 2023
$429k
NIDA NIH HHS R01 DA054967NIDA NIH HHS R01 DA057084NIDA NIH HHS T32 DA024635NIMH NIH HHS R21 MH126278
6 · The paper itself

Abstract

Despite the physiological complexity of the hypothalamus, its role is typically restricted to initiation or cessation of innate behaviors. For example, theories of lateral hypothalamus argue that it is a switch to turn feeding 'on' and 'off' as dictated by higher-order structures that render when feeding is appropriate. However, recent data demonstrate that the lateral hypothalamus is critical for learning about food-related cues. Furthermore, the lateral hypothalamus opposes learning about information that is neutral or distal to food. This reveals the lateral hypothalamus as a unique arbitrator of learning capable of shifting behavior toward or away from important events. This has relevance for disorders characterized by changes in this balance, including addiction and schizophrenia. Generally, this suggests that hypothalamic function is more complex than increasing or decreasing innate behaviors.

Indexed as

Hypothalamic Area, LateralHypothalamusCognitionCuesHumansLearningRewardaddictionfeedinglateral hypothalamusreinforcement learningrewardschizophrenia

Identifiers

PMID37758590
PMCPMC10841673

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.