Evidence map›Paper›PMID 37758537›Full record

ArticleTrends in pharmacological sciences2023

Lighting the way to tumor destruction.

Christina C Kuismi, Behnam Nabet

Open access · greenAbstract readComment
In one paragraph

Article in Trends in pharmacological sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Non-coding RNA and drug resistance in head and neck cancer.Cancer drug resistance (Alhambra, Calif.) · 2024
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 2 countries.

Christina C KuismiHuman Biology Division, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA.
Behnam NabetHuman Biology Division, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA. Electronic address: bnabet@fredhutch.org.
Cape Town HVTN Immunology Laboratory / Hutchinson Centre Research Institute of South Africa · ZAFred Hutch Cancer Center · US

Funding

Translational Bioimaging Core Shared ResourceP30CA015704 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI Eric Collisson · 1985 to 2026
$296.4M
Targeted disruption of the YAP/TAZ/TEAD axis in pancreatic cancerK22CA258805 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI NABET, BEHNAM · 2021 to 2024
$644k
NCI NIH HHS K22 CA258805NCI NIH HHS P30 CA015704
6 · The paper itself

Abstract

Achieving tumor-specific protein loss remains a challenge in the delivery of proteolysis-targeting chimeras (PROTACs) as cancer therapeutics. As a solution, Wang et al. recently developed nanoformulated PROTACs (NAPs), a novel photoactivatable degradation approach. This innovative class of compounds harnesses near-infrared (NIR) light for precise PROTAC release and protein degradation in mouse tumors.

Indexed as

NeoplasmsAnimalsMiceProteolysisUbiquitin-Protein LigasesUbiquitin-Protein Ligasescancernanoformulated PROTACphotoactivationprecision therapyPROTACtargeted protein degradation

Identifiers

PMID37758537
PMCPMC10691509
OpenAlexW4387009327

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.