ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2023
The Structure of Hippocampal CA1 Interactions Optimizes Spatial Coding across Experience.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Article
- Three types of remapping with linear decoders: A population-geometric perspective.PLoS computational biology · 2025Article
- Three types of remapping with linear decoders: a population-geometric perspective.bioRxiv : the preprint server for biology · 2025Article
- Novel ANKRD17 variants implicate synaptic and mitochondrial disruptions in intellectual disability and autism spectrum disorder.Journal of neurodevelopmental disorders · 2025Article
- Dynamic structure of motor cortical neuron coactivity carries behaviorally relevant information.Network neuroscience (Cambridge, Mass.) · 2023Article
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Authors and funding
4 authors.
Funding
Abstract
Although much is known about how single neurons in the hippocampus represent an animal's position, how circuit interactions contribute to spatial coding is less well understood. Using a novel statistical estimator and theoretical modeling, both developed in the framework of maximum entropy models, we reveal highly structured CA1 cell-cell interactions in male rats during open field exploration. The statistics of these interactions depend on whether the animal is in a familiar or novel environment. In both conditions the circuit interactions optimize the encoding of spatial information, but for regimes that differ in the informativeness of their spatial inputs. This structure facilitates linear decodability, making the information easy to read out by downstream circuits. Overall, our findings suggest that the efficient coding hypothesis is not only applicable to individual neuron properties in the sensory periphery, but also to neural interactions in the central brain.
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Registered trials
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