ArticleFEMS microbiology letters2023
Analysis of BlaEC family class C beta-lactamase.
Article in FEMS microbiology letters, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed.
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- Article
- Whole-Genome Analysis of Multidrug-Resistant Escherichia coli from Bloodstream Infections in Iraqi Cancer Patients.Asian Pacific journal of cancer prevention : APJCP · 2026Article
- Genetic Basis of Multiple Antibiotic Resistance of PathogenicInternational journal of molecular sciences · 2025Article
- Genomic and Drug Resistance Profile of Bovine Multidrug-ResistantPathogens (Basel, Switzerland) · 2025Article
- AmpC β-lactamases detected in Southeast AsianJAC-antimicrobial resistance · 2024Article
- The Impact of Urban Pollution on Plasmid-Mediated Resistance Acquisition in Enterobacteria from a Tropical River.Antibiotics (Basel, Switzerland) · 2024Article
- Molecular Characterization of Multidrug-ResistantVeterinary sciences · 2024Article
- Draft genome of a human-derivedMicrobiology resource announcements · 2024Article
- Rapid Phenotypic Antibiotic Susceptibility Profiling of ClinicalAntibiotics (Basel, Switzerland) · 2024Article
- Gut resistome of NSCLC patients treated with immunotherapy.Frontiers in genetics · 2024Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Recent years have witnessed an increased prevalence of intrinsic and acquired beta-lactamase-producing bacteria, severely limiting human and veterinary medicine therapeutic options. The present study aimed to design specific oligonucleotides for rapid PCR detection of the cephalosporinase-encoding gene blaEC (BlaEC family class C beta-lactamase). A total of three primers were designed to detect 2281 variants of the blaEC gene and two sets of primer pairs were also tested against DNA from 11 strains. The study indicates that the proposed primers should be able to detect 100% of all described blaEC genes in different bacterial strains and monitor their spread. After comparing the amino acid sequences, a phylogenetic tree was created based on the presence of conserved amino acids and homologous motifs. More than 24 760 mutations in BlaEC enzymes have been identified. The mutations involving 371 amino acid positions and these hotspots can change the structure and activity of the monitored enzymes. We predicted several BlaEC enzymes with a broadened substrate activity against higher-generation cephalosporins.
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Registered trials
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