ArticleScience advances2023
The phenotype and genotype of fermentative prokaryotes.
Article in Science advances, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Microbe Decoder uncovers functional traits of microbes in microbiome datasets.Nucleic acids research · 2026Article
- Organic carbon oxidation state shapes fermentative methanogenic microbiomes and controls greenhouse gas fluxes.Nature communications · 2026Article
- Pseudomonas aeruginosa Relies on a Phosphoketolase to Support Anaerobic Survival Under Reductive Stress.Molecular microbiology · 2026Article
- Successional Trajectories of Deep Subsurface Microbiomes in Response To Experimental Dihydrogen Injection.Microbial ecology · 2026Article
- Fermentative nitrite ammonifiers are abundant in soils and ecologically distinct from NrfA-dependent ammonifiers.ISME communications · 2026Article
- Using gnotobiotic ruminants to dissect host-microbe interactions for sustainable agriculture.Frontiers in microbiology · 2026Article
- Metabolic controls on the carbon isotope fractionations of bacterial fermentation.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Parabacteroides absconsus sp. nov., isolated from feces of a child with atopic dermatitis.Archives of microbiology · 2025Article
- Isolation ofJDS communications · 2025Article
- Article
- The vast landscape of carbohydrate fermentation in prokaryotes.FEMS microbiology reviews · 2024Review
- The oxidoreductase activity of Rnf balances redox cofactors during fermentation of glucose to propionate in Prevotella.Scientific reports · 2023Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Fermentation is a type of metabolism pervasive in oxygen-deprived environments. Despite its importance, we know little about the range and traits of organisms that carry out this metabolism. Our study addresses this gap with a comprehensive analysis of the phenotype and genotype of fermentative prokaryotes. We assembled a dataset with phenotypic records of 8350 organisms plus 4355 genomes and 13.6 million genes. Our analysis reveals fermentation is both widespread (in ~30% of prokaryotes) and complex (forming ~300 combinations of metabolites). Furthermore, it points to previously uncharacterized proteins involved in this metabolism. Previous studies suggest that metabolic pathways for fermentation are well understood, but metabolic models built in our study show gaps in our knowledge. This study demonstrates the complexity of fermentation while showing that there is still much to learn about this metabolism. All resources in our study can be explored by the scientific community with an online, interactive tool.
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