Evidence map›Paper›PMID 37756379›Full record

ArticleScience translational medicine2023

A MERS-CoV antibody neutralizes a pre-emerging group 2c bat coronavirus.

Longping V Tse, Yixuan J Hou, Elizabeth McFadden, Rhianna E Lee, Trevor D Scobey, Sarah R Leist, David R Martinez, Rita M Meganck, Alexandra Schäfer, Boyd L Yount and 8 more

Open access · greenAbstract read
In one paragraph

Article in Science translational medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
7.0field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 36 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 4 institutions in 2 countries.

Longping V TseDepartment of Molecular Microbiology and Immunology, Saint Louis University, St. Louis, MO 63014, USA.ORCID 0000-0001-7582-8396
Yixuan J HouDepartment of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.ORCID 0000-0002-8323-7243
Elizabeth McFaddenDepartment of Molecular Biosciences, University of Texas at Austin, Austin, TX 78712, USA.ORCID 0000-0003-1440-1094
Rhianna E LeeMarsico Lung Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.ORCID 0000-0003-2039-1304
Trevor D ScobeyDepartment of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Sarah R LeistDepartment of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.ORCID 0000-0002-4989-5381
David R MartinezDepartment of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.ORCID 0000-0002-2940-8961
Rita M MeganckDepartment of Molecular Microbiology and Immunology, Saint Louis University, St. Louis, MO 63014, USA.ORCID 0000-0003-2799-3754
Alexandra SchäferDepartment of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.ORCID 0000-0002-4760-4923
Boyd L YountDepartment of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Teresa MascenikMarsico Lung Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.ORCID 0000-0002-9694-756X
John M PowersDepartment of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.ORCID 0000-0002-0485-9109
Scott H RandellMarsico Lung Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.ORCID 0000-0001-5351-2841
Yi ZhangNational Institute of Allergy and Infectious Disease, National Institute of Health, Bethesda, MD 20892, USA.ORCID 0000-0002-8228-2560
Lingshu WangNational Institute of Allergy and Infectious Disease, National Institute of Health, Bethesda, MD 20892, USA.ORCID 0000-0002-8404-4910
John MascolaNational Institute of Allergy and Infectious Disease, National Institute of Health, Bethesda, MD 20892, USA.
Jason S McLellanDepartment of Molecular Biosciences, University of Texas at Austin, Austin, TX 78712, USA.ORCID 0000-0003-3991-542X
Ralph S BaricDepartment of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.ORCID 0000-0001-6827-8701
University of North Carolina at Chapel Hill · USNational Institute of Allergy and Infectious Diseases · USSaint Louis University · ESThe University of Texas at Austin · US

Funding

Research Project 1: Coronavirus antiviral lead development and combination testingU19AI171292 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BARIC, RALPH S, WILLSON, TIMOTHY M · 2022 to 2022
$65.5M
Project 4: Computational panbetaCoV immunogen designP01AI158571 · NIAID · DUKE UNIVERSITY · PI HENDERSON, RORY · 2021 to 2023
$28.0M
Structure-based design of broadly protective coronavirus vaccinesP01AI167966 · NIAID · UNIVERSITY OF WASHINGTON · PI BALI PULENDRAN · 2022 to 2026
$15.3M
Stanford/UNC Biomimetic U19 Research CenterU19AI116484 · NIAID · STANFORD UNIVERSITY · PI KUO, CALVIN J · 2015 to 2025
$13.5M
Project 3: Serological Interactions with the Mucosal Innate Immune System Regulates COVID-19 Associated Tissue Damage.U54CA260543 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI WOLFGANG, MATTHEW C · 2020 to 2024
$9.8M
Broad-spectrum antiviral GS-5734 to treat MERS-CoV and related emerging CoVR01AI132178 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BARIC, RALPH S, SHEAHAN, TIMOTHY PATRICK · 2017 to 2021
$7.0M
Understanding Risk of Zoonotic Virus Emergence in EID Hotspots of Southeast AsiaU01AI151797 · NIAID · ECOHEALTH ALLIANCE, INC. · PI DASZAK, PETER · 2020 to 2023
$6.0M
Structure, Function and Antigenicity of Coronavirus Spike ProteinsR01AI127521 · NIAID · UNIVERSITY OF TEXAS AT AUSTIN · PI MCLELLAN, JASON SCOTT, WARD, ANDREW BARRETT · 2017 to 2021
$3.1M
NCI NIH HHS U54 CA260543NIAID NIH HHS P01 AI158571NIAID NIH HHS P01 AI167966NIAID NIH HHS R01 AI127521NIAID NIH HHS R01 AI132178NIAID NIH HHS U01 AI151797NIAID NIH HHS U19 AI116484NIAID NIH HHS U19 AI171292
6 · The paper itself

Abstract

The repeated emergence of zoonotic human betacoronaviruses (β-CoVs) dictates the need for broad therapeutics and conserved epitope targets for countermeasure design. Middle East respiratory syndrome (MERS)-related coronaviruses (CoVs) remain a pressing concern for global health preparedness. Using metagenomic sequence data and CoV reverse genetics, we recovered a full-length wild-type MERS-like BtCoV/

Indexed as

ChiropteraCoronavirus InfectionsMiddle East Respiratory Syndrome CoronavirusAnimalsAntibodies, MonoclonalCryoelectron MicroscopyDipeptidyl Peptidase 4HumansMiceAntibodies, MonoclonalDipeptidyl Peptidase 4

Identifiers

PMID37756379
PMCPMC11292784
OpenAlexW4387091695

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.