ArticleProceedings of the National Academy of Sciences of the United States of America2023
Intrinsic disorder and conformational coexistence in auxin coreceptors.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed, 10 citations in OpenAlex.
- Self-Guided Molecular Simulation Methods.International journal of molecular sciences · 2025Review
- A deletion upstream of the degron of AcIAA27 leads to auxinic herbicide resistance in Arctotheca calendula.Pest management science · 2025Article
- Recent Developments in Amber Biomolecular Simulations.Journal of chemical information and modeling · 2025Article
- A point mutation in IAA34 confers resistance to the auxin herbicide 2,4-D in Sisymbrium orientale.Pest management science · 2025Article
- A transposable element insertion in AUX/IAA16 disrupts splicing and causes auxin resistance in Bassia scoparia.The Plant journal : for cell and molecular biology · 2025Article
- An auxin research odyssey: 1989-2023.The Plant cell · 2024Review
- Auxin research: creating tools for a greener future.Journal of experimental botany · 2023Article
- Transcriptional Tuning: How Auxin Strikes Unique Chords in Gene Regulation.Physiologia plantarumReview
Corrections and comments
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Authors and funding
13 authors at 5 institutions in 2 countries.
Funding
Abstract
AUXIN/INDOLE 3-ACETIC ACID (Aux/IAA) transcriptional repressor proteins and the TRANSPORT INHIBITOR RESISTANT 1/AUXIN SIGNALING F-BOX (TIR1/AFB) proteins to which they bind act as auxin coreceptors. While the structure of TIR1 has been solved, structural characterization of the regions of the Aux/IAA protein responsible for auxin perception has been complicated by their predicted disorder. Here, we use NMR, CD and molecular dynamics simulation to investigate the N-terminal domains of the Aux/IAA protein IAA17/AXR3. We show that despite the conformational flexibility of the region, a critical W-P bond in the core of the Aux/IAA degron motif occurs at a strikingly high (1:1) ratio of
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.