ArticleEnvironmental science & technology2023
Paired Liver:Plasma PFAS Concentration Ratios from Adolescents in the Teen-LABS Study and Derivation of Empirical and Mass Balance Models to Predict and Explain Liver PFAS Accumulation.
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Article in Environmental science & technology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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21 citing papers in PubMed, 37 citations in OpenAlex.
- Sex-Specific Associations Between Per- and Polyfluoroalkyl Substances and the Risk of Type 2 Diabetes: The Role of Genetic Susceptibility and Lipid Metabolism.Environmental health perspectives · 2026Article
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- Toxicological Effects and Health Impacts of Per- and Polyfluoroalkyl Substances (PFAS) in Humans.Toxics · 2026Review
- Presence of Legacy and Emerging PFAS in Human Liver Specimens Banked in the United States from 2000 to 2024.Environmental science & technology · 2026Article
- Forever Chemicals, Finite Defenses: PFAS Burden the Liver, Break Mitochondria, and Outpace Modern Regulation.International journal of molecular sciences · 2026Review
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- Evaluations of Sex Differences in Dosimetry in Rats Following Perfluorohexanesulfonamide (PFHxSA) Oral Exposure.Toxics · 2025Article
- Translational framework linking perfluoroheptanoic acid (PFHpA) exposure to metabolic dysfunction associated steatotic liver disease in adolescents.Communications medicine · 2025Article
- Per- and Polyfluoroalkyl Substances (PFAS) Enhance Cholesterol Accumulation and Dysregulate Inflammatory Responses in Macrophages.Cardiovascular toxicology · 2025Article
- PFAS Exposure and Postoperative Weight Regain in Adolescents After Bariatric Surgery: Findings From the Teen-LABS Study.Obesity (Silver Spring, Md.) · 2025Observational
- Liver and Intestinal Fatty Acid Binding Proteins Are Not Critical for Perfluorooctanesulfonate (PFOS) Tissue Distribution and Elimination in Mice.Chemical research in toxicology · 2025Article
- Assessing the impact of perfluoroalkyl substances on liver health: a comprehensive study using multi-donor human liver spheroids.Environment international · 2025Article
- Broad PFAS Binding with Fatty Acid Binding Protein 4 Is Enabled by Variable Binding Modes.JACS Au · 2025Article
- Perfluorooctanoic acid increases serum cholesterol in a PPARα-dependent manner in female mice.Archives of toxicology · 2025Article
- Per- and Polyfluoroalkyl Substances (PFAS) in Consumer Products: An Overview of the Occurrence, Migration, and Exposure Assessment.Molecules (Basel, Switzerland) · 2025Review
- Exposure to per- and polyfluoroalkyl substances and alterations in plasma microRNA profiles in children.Environmental research · 2024Article
- Unbound Fractions of PFAS in Human and Rodent Tissues: Rat Liver a Suitable Proxy for Evaluating Emerging PFAS?Environmental science & technology · 2024Article
- Changes in plasma concentrations of per- and Polyfluoroalkyl substances after bariatric surgery in adolescents from the Teen-Longitudinal Assessment of Bariatric Surgery (Teen-LABS) study.The Science of the total environment · 2024Article
- Species Difference? Bovine, Trout, and Human Plasma Protein Binding of Per- and Polyfluoroalkyl Substances.Environmental science & technology · 2024Article
- Article
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Authors and funding
19 authors at 13 institutions in 3 countries.
Brittney O BaumertDepartment of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, California 90032, United States.ORCID 0000-0003-1220-8557
Fabian C FischerJohn A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, Massachusetts 02134, United States.
Flemming NielsenInstitute of Public Health, University of Southern Denmark, Odense 5230, Denmark.
Philippe GrandjeanInstitute of Public Health, University of Southern Denmark, Odense 5230, Denmark.
Scott BartellDepartment of Environmental and Occupational Health, University of California, Irvine, California 92697, United States.
Nikos StratakisBarcelona Institute for Global Health, ISGlobal, Dr. Aiguader 88, 08003 Barcelona, Spain.
Douglas I WalkerGangarosa Department of Environmental Health, Rollins School of Public Health, Emory University, 1518 Clifton Road, NE, Atlanta, Georgia 30322, United States.
Damaskini ValviDepartment of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, New York 10029, United States.
Rohit KohliDivision of Gastroenterology, Hepatology and Nutrition, Children's Hospital Los Angeles, Los Angeles, California 90027, United States.
Thomas IngeDepartment of Surgery, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, United States.
Justin RyderDepartment of Surgery, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, United States.
Todd JenkinsCincinnati Children's Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio 45229, United States.
Stephanie SisleyDepartment of Pediatrics, USDA/ARS Children's Nutrition Research Center, Baylor College of Medicine, Houston, Texas 77030, United States.
Stavra XanthakosCincinnati Children's Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio 45229, United States.
Sarah RockDepartment of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, California 90032, United States.
Michele A La MerrillDepartment of Environmental Toxicology, University of California, Davis, California 95616, United States.ORCID 0000-0002-5720-5862
David ContiDepartment of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, California 90032, United States.
Rob McConnellDepartment of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, California 90032, United States.
Lida ChatziDepartment of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, California 90032, United States.
University of Southern California · USCincinnati Children's Hospital Medical Center · USNorthwestern University · USBarcelona Institute for Global Health · ESChildren's Hospital of Los Angeles · USChildren's Nutrition Research Center at Baylor College of Medicine · USEmory University · USHarvard University · USIcahn School of Medicine at Mount Sinai · USUniversity of California, Davis · USUniversity of California, Irvine · USUniversity of Rhode Island · USUniversity of Southern Denmark · DK
Funding
Translational Research Support CoreP30ES007048 · NIEHS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI ROB S MCCONNELL · 1996 to 2026
$46.4MStatistical Methods for Integrative Genomics in CancerP01CA196569 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Paul Marjoram · 2016 to 2026
$25.5MThe Mount Sinai Transdisciplinary Center on Early Environmental ExposuresP30ES023515 · NIEHS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Manish Arora · 2014 to 2026
$21.3MSources, Transport, Exposure & Effects of PFAS (STEEP) Center - RENEWALP42ES027706 · NIEHS · UNIVERSITY OF RHODE ISLAND · PI Elsie Mareca Sunderland · 2017 to 2026
$18.9MTeen Longitudinal Assessment of Bariatric Surgery (Teen-LABS) Research ProjectUM1DK072493 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI INGE, THOMAS HARRIS · 2011 to 2020
$10.5MTeen Longitudinal Assessment of Bariatric Surgery (Teen-LABS) renewalUM1DK095710 · NIDDK · UNIVERSITY OF CINCINNATI · PI JENKINS, TODD M, XIE, CHANGCHUN · 2011 to 2020
$9.4MUntargeted Analysis ResourceU2CES030859 · NIEHS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI ARORA, MANISH · 2019 to 2025
$8.2MTraining Grant in Genomic Analysis and InterpretationT32ES013678 · NIEHS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI GAUDERMAN, WILLIAM JAMES, MCCONNELL, ROB S · 2006 to 2023
$5.6MTranslation CoreP2CES033433 · NIEHS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Jill E Johnston, Elizabeth Mary Kamai · 2022 to 2026
$4.9MEffects of DDE exposure on adipose tissue function, weight loss and metabolic improvement after bariatric surgery: A new paradigm for study of lipophilic chemicalsR01ES030364 · NIEHS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI CHATZI, VAIA LIDA · 2020 to 2024
$3.2MPerfluoroalkyl substances and incident type 2 diabetes in a US population: A metabolome-genome investigationR01ES033688 · NIEHS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Damaskini Valvi · 2022 to 2026
$3.2MEnvironmental Chemical Exposures and Longitudinal Changes of Glucose Metabolism, Insulin Sensitivity and B Cell Function in YouthR01ES029944 · NIEHS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI CHATZI, VAIA LIDA · 2019 to 2023
$3.1MNCI NIH HHS P01 CA196569NIDDK NIH HHS R01 DK128117NIDDK NIH HHS UM1 DK072493NIDDK NIH HHS UM1 DK095710NIEHS NIH HHS P2C ES033433NIEHS NIH HHS P30 ES007048NIEHS NIH HHS P30 ES023515NIEHS NIH HHS P42 ES027706NIEHS NIH HHS R01 ES029944NIEHS NIH HHS R01 ES030364NIEHS NIH HHS R01 ES030691NIEHS NIH HHS R01 ES032831NIEHS NIH HHS R01 ES033688NIEHS NIH HHS R21 ES028903NIEHS NIH HHS R21 ES029328NIEHS NIH HHS R21 ES029681NIEHS NIH HHS R21 ES035148NIEHS NIH HHS T32 ES013678NIEHS NIH HHS U2C ES030859
Abstract
Animal studies have pointed at the liver as a hotspot for per- and polyfluoroalkyl substances (PFAS) accumulation and toxicity; however, these findings have not been replicated in human populations. We measured concentrations of seven PFAS in matched liver and plasma samples collected at the time of bariatric surgery from 64 adolescents in the Teen-Longitudinal Assessment of Bariatric Surgery (Teen-LABS) study. Liver:plasma concentration ratios were perfectly explained (
Indexed as
Alkanesulfonic AcidsBariatric SurgeryEnvironmental PollutantsFluorocarbonsAdolescentAnimalsCohort StudiesHeptanoic AcidsHumansLiverAlkanesulfonic AcidsEnvironmental PollutantsFluorocarbonsHeptanoic Acidsperfluoro-n-heptanoic acidbiopsy samplescorrelationhuman exposureliver accumulationPFAStoxicokinetics
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