ArticleIEEE transactions on ultrasonics, ferroelectrics, and frequency control2023
Longitudinal 3-D Visualization of Microvascular Disruption and Perfusion Changes in Mice During the Evolution of Glioblastoma Using Super-Resolution Ultrasound.
Article in IEEE transactions on ultrasonics, ferroelectrics, and frequency control, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- In Vivo Wide-Field Mapping of Microvascular Dynamics in Orthotopic GL261 Gliomas by Super-Resolution Ultrasound Imaging.Annals of biomedical engineering · 2026Article
- Feasibility of deep learning-based cancer detection in ultrasound microvascular images.Ultrasonics · 2026Article
- Crosstalk in the brain tumor microenvironment: mechanisms, therapeutic strategies, and clinical advances.Military Medical Research · 2026Review
- Laser Ultrasound Super-Resolution Imaging for Multi-Parametric Non-Invasive Volumetric Characterization of Brain Cancer.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Ultrasound matrix imaging for 3D transcranial in vivo localization microscopy.Science advances · 2025Article
- Improving Imaging Field of View of 3-D Transcranial Rat Brain Super-Resolution With Robotic Registered Compounding and Nonrigid Deformation Correction.IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2025Article
- Microvascular heterogeneity exploration in core and invasive zones of orthotopic rat glioblastoma via ultrasound localization microscopy.European radiology experimental · 2025Article
- Non-invasive volumetric ultrasound localization microscopy detects vascular changes in mice with Alzheimer's disease.Theranostics · 2025Article
- 3D ultrasound localization microscopy of the nonhuman primate brain.EBioMedicine · 2025Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Glioblastoma is an aggressive brain cancer with a very poor prognosis in which less than 6% of patients survive more than five-year post-diagnosis. The outcome of this disease for many patients may be improved by early detection. This could provide clinicians with the information needed to take early action for treatment. In this work, we present the utilization of a non-invasive, fully volumetric ultrasonic imaging method to assess microvascular change during the evolution of glioblastoma in mice. Volumetric ultrasound localization microscopy (ULM) was used to observe statistically significant ( ) reduction in the appearance of functional vasculature over the course of three weeks. We also demonstrate evidence suggesting the reduction of vascular flow for vessels peripheral to the tumor. With an 82.5% consistency rate in acquiring high-quality vascular images, we demonstrate the possibility of volumetric ULM as a longitudinal method for microvascular characterization of neurological disease.
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