Evidence map›Paper›PMID 37756163›Full record

ArticleCell reports2023

Microenvironmental stiffness induces metabolic reprogramming in glioblastoma.

Alireza Sohrabi, Austin E Y T Lefebvre, Mollie J Harrison, Michael C Condro, Talia M Sanazzaro, Gevick Safarians, Itay Solomon, Soniya Bastola, Shadi Kordbacheh, Nadia Toh and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed
9.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 44 citations in OpenAlex.

  1. Review
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  5. Beyond DNA damage: 3D tumor models and the integrin mechanobiology of radioresistance.Journal of experimental & clinical cancer research : CR · 2026
    Review
  6. Review
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  8. Article
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  11. Mechanotherapeutic Potential of Survivin in Glioblastoma.bioRxiv : the preprint server for biology · 2026
    Article
  12. Article
  13. Hydrogel Microdroplet Based Glioblastoma Drug Screening Platform.Journal of biomedical materials research. Part A · 2026
    Article
  14. Modulation of the Mechanosensory Matrisome by Serotonergic Signaling.Results and problems in cell differentiation · 2026
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 1 country.

Alireza SohrabiDepartment of Biomedical Engineering, University of Texas at Austin, Austin, TX 78712, USA; Department of Bioengineering, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Austin E Y T LefebvreDepartment of Biomedical Engineering, University of California at Irvine, Irvine, CA 92697, USA.
Mollie J HarrisonDepartment of Biomedical Engineering, University of Texas at Austin, Austin, TX 78712, USA.
Michael C CondroDepartment of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Talia M SanazzaroDepartment of Biomedical Engineering, University of Texas at Austin, Austin, TX 78712, USA.
Gevick SafariansDepartment of Bioengineering, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Itay SolomonDepartment of Bioengineering, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Soniya BastolaDepartment of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Shadi KordbachehDepartment of Bioengineering, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Nadia TohDepartment of Biomedical Engineering, University of Texas at Austin, Austin, TX 78712, USA.
Harley I KornblumDepartment of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Michelle A DigmanDepartment of Biomedical Engineering, University of California at Irvine, Irvine, CA 92697, USA.
Stephanie K SeidlitsDepartment of Biomedical Engineering, University of Texas at Austin, Austin, TX 78712, USA; Department of Bioengineering, University of California, Los Angeles, Los Angeles, CA 90095, USA. Electronic address: seidlits@utexas.edu.
University of California, Los Angeles · USThe University of Texas at Austin · USUniversity of California, Irvine · US

Funding

UCLA SPORE in Brain CancerP50CA211015 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Yvonne Yu-Hsuan Chen · 2017 to 2026
$25.2M
Radiation-induced vascular reprogramming in glioblastomaR01NS121617 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI HARLEY IAN KORNBLUM · 2022 to 2026
$2.3M
Tissue-Engineered Models of Microvessel-Mediated Glioblastoma InvasionR01CA241927 · NCI · UNIVERSITY OF TEXAS AT AUSTIN · PI SEIDLITS, STEPHANIE KRISTIN · 2020 to 2024
$1.9M
NCI NIH HHS P50 CA211015NCI NIH HHS R01 CA241927NINDS NIH HHS R01 NS121617
6 · The paper itself

Abstract

The mechanical properties of solid tumors influence tumor cell phenotype and the ability to invade surrounding tissues. Using bioengineered scaffolds to provide a matrix microenvironment for patient-derived glioblastoma (GBM) spheroids, this study demonstrates that a soft, brain-like matrix induces GBM cells to shift to a glycolysis-weighted metabolic state, which supports invasive behavior. We first show that orthotopic murine GBM tumors are stiffer than peritumoral brain tissues, but tumor stiffness is heterogeneous where tumor edges are softer than the tumor core. We then developed 3D scaffolds with μ-compressive moduli resembling either stiffer tumor core or softer peritumoral brain tissue. We demonstrate that the softer matrix microenvironment induces a shift in GBM cell metabolism toward glycolysis, which manifests in lower proliferation rate and increased migration activities. Finally, we show that these mechanical cues are transduced from the matrix via CD44 and integrin receptors to induce metabolic and phenotypic changes in cancer cells.

Indexed as

Brain NeoplasmsGlioblastomaAnimalsBrainCell Line, TumorHumansMiceTumor MicroenvironmentCP: CancerCP: Metabolismextracellular matrixtissue mechanics

Identifiers

PMID37756163
PMCPMC10842372
OpenAlexW4387045429

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.