Evidence map›Paper›PMID 37755992›Full record

ArticleToxins2023

Longitudinal Assessment of Botulinum Toxin Treatment for Lateral Trunk Flexion and Pisa Syndrome in Parkinson's Disease: Real-life, Long-Term Study.

Claudia Ledda, Elisa Panero, Ugo Dimanico, Mattia Parisi, Marialuisa Gandolfi, Michele Tinazzi, Christian Geroin, Francesco Marchet, Giuseppe Massazza, Leonardo Lopiano and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Toxins, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
1.2field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 6 citations in OpenAlex.

  1. Pooled it
  2. Efficacy and safety ofBMC neurology · 2026
    Trial
  3. Review
  4. Article
  5. Observational
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 1 country.

Claudia LeddaDepartment of Neuroscience "Rita Levi Montalcini", University of Turin, 10126 Turin, Italy.
Elisa PaneroPhysical Medicine and Rehabilitation Unit, Department of Orthopedics, Traumatology and Rehabilitation, University of Turin, 10126 Turin, Italy.ORCID 0000-0002-5555-5818
Ugo DimanicoPhysical Medicine and Rehabilitation Unit, Department of Orthopedics, Traumatology and Rehabilitation, University of Turin, 10126 Turin, Italy.
Mattia ParisiDepartment of Neurology, Ospedale Rivoli, Rivoli, 10098 Turin, Italy.
Marialuisa GandolfiNeurology Unit, Movement Disorders Division, Department of Neurosciences Biomedicine and Movement Sciences, University of Verona, 37129 Verona, Italy.ORCID 0000-0002-0877-4807
Michele TinazziNeurology Unit, Movement Disorders Division, Department of Neurosciences Biomedicine and Movement Sciences, University of Verona, 37129 Verona, Italy.
Christian GeroinNeurology Unit, Movement Disorders Division, Department of Neurosciences Biomedicine and Movement Sciences, University of Verona, 37129 Verona, Italy.
Francesco MarchetDepartment of Human Neurosciences, Sapienza University of Rome, Viale dell'Università 30, 00185 Rome, Italy.
Giuseppe MassazzaPhysical Medicine and Rehabilitation Unit, Department of Orthopedics, Traumatology and Rehabilitation, University of Turin, 10126 Turin, Italy.
Leonardo LopianoDepartment of Neuroscience "Rita Levi Montalcini", University of Turin, 10126 Turin, Italy.
Carlo Alberto ArtusiDepartment of Neuroscience "Rita Levi Montalcini", University of Turin, 10126 Turin, Italy.ORCID 0000-0001-8579-3772
Azienda Ospedaliera Citta' della Salute e della Scienza di Torino · ITUniversity of Turin · ITUniversity of Verona · ITOspedale di Rivoli · ITSapienza University of Rome · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Lateral trunk flexion (LTF) and its severe form, called Pisa syndrome (PS), are highly invalidating axial postural abnormalities associated with Parkinson's disease (PD). Management strategies for LTF lack strong scientific evidence. We present a real-life, longitudinal study evaluating long-term efficacy of botulinum toxin (BoNT) injections in axial muscles to reduce LTF and PS in PD. A total of 13 PD patients with LTF > 5° received ultrasound- and electromyography-guided BoNT injections every 4 months. Seven untreated matched PD patients with LTF served as controls and their changes in posture after 18 months were compared with those of seven patients continuing BoNT over 12 months. 53.8% of patients continued the BoNT injections for at least 12 months. Various individual LTF responses were observed. Overall, BoNT-treated patients obtained a not statistically significant improvement of LTF of 17 ± 41% (

Indexed as

Botulinum ToxinsParkinson DiseaseElectromyographyHumansLongitudinal StudiesMusclesSyndromeBotulinum Toxinsbotulinum toxinlateral trunk flexionParkinson’s diseasePisa syndrome

Identifiers

PMID37755992
PMCPMC10536312
OpenAlexW4386616233

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.