ArticleToxics2023
Differential Susceptibility to Benzo[a]pyrene Exposure during Gestation and Lactation in Mice with Genetic Variations in the Aryl Hydrocarbon Receptor and
Mackenzie Feltner, Patrick M Hare, Asia Good, Emma G Foster, Katelyn Clough, Jade Perry, Amanda Honaker, Angela Kyntchev, Mickayla Kowalski, Christine Perdan Curran
Open access · goldAbstract read
In one paragraphArticle in Toxics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.2field-weighted citation impact, top 49% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed, 1 citations in OpenAlex.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
10 authors at 1 institution in 1 country.
Mackenzie FeltnerDepartment of Biological Sciences, Northern Kentucky University, Highland Heights, KY 41099, USA.
Patrick M HareDepartment of Chemistry & Biochemistry, Northern Kentucky University, Highland Heights, KY 41099, USA.ORCID 0000-0001-8348-161X Asia GoodDepartment of Biological Sciences, Northern Kentucky University, Highland Heights, KY 41099, USA.
Emma G FosterDepartment of Biological Sciences, Northern Kentucky University, Highland Heights, KY 41099, USA.ORCID 0000-0003-1241-1918 Katelyn CloughDepartment of Biological Sciences, Northern Kentucky University, Highland Heights, KY 41099, USA.ORCID 0009-0000-4581-6327 Jade PerryDepartment of Biological Sciences, Northern Kentucky University, Highland Heights, KY 41099, USA.
Amanda HonakerDepartment of Biological Sciences, Northern Kentucky University, Highland Heights, KY 41099, USA.
Angela KyntchevDepartment of Biological Sciences, Northern Kentucky University, Highland Heights, KY 41099, USA.
Mickayla KowalskiDepartment of Biological Sciences, Northern Kentucky University, Highland Heights, KY 41099, USA.
Christine Perdan CurranDepartment of Biological Sciences, Northern Kentucky University, Highland Heights, KY 41099, USA.
Northern Kentucky University · US
Funding
WKU Lead Faculty AwardP20GM103436 · NIGMS · UNIVERSITY OF LOUISVILLE · PI ERIC C ROUCHKA · 2012 to 2026
$60.1MZEBRAFISH VISUAL FUNCTION RECOVERY FOLLOWING OPTIC NERVE DAMAGEP20RR016481 · NCRR · UNIVERSITY OF LOUISVILLE · PI COOPER, NIGEL G.F. · 2001 to 2011
$34.8MGenetic Susceptibility to Developmental Benzo[a]pyrene NeurotoxicityR15ES030541 · NIEHS · NORTHERN KENTUCKY UNIVERSITY · PI CURRAN, CHRISTINE PERDAN · 2019 to 2023
$818kGenetic Susceptibility to PCB-induced Motor DysfunctionR15ES020053 · NIEHS · NORTHERN KENTUCKY UNIVERSITY · PI CURRAN, CHRISTINE PERDAN · 2012 to 2014
$419kNCRR NIH HHS P20 RR016481NIEHS NIH HHS R15 ES020053NIEHS NIH HHS R15ES020053NIEHS NIH HHS R15 ES030541NIGMS NIH HHS P20 GM103436NIGMS NIH HHS P20GM103436
6 · The paper itselfAbstract
Polycyclic aromatic hydrocarbons are ubiquitous air pollutants, with additional widespread exposure in the diet. PAH exposure has been linked to adverse birth outcomes and long-term neurological consequences. To understand genetic differences that could affect susceptibility following developmental exposure to polycyclic aromatic hydrocarbons, we exposed mice with variations in the aryl hydrocarbon receptor and the three CYP1 enzymes from gestational day 10 (G10) to weaning at postnatal day 25 (P25). We found unexpectedly high neonatal lethality in high-affinity
Indexed as
aryl hydrocarbon receptorbenzo[a]pyreneCYP1A1CYP1A2CYP1B1neonatal lethalitypolycyclic aromatic hydrocarbons
Identifiers
PMID37755789
PMCPMC10537487
OpenAlexW4386712761
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390