Evidence map›Paper›PMID 37755744›Full record

ArticleToxics2023

Molecular Mechanisms of Selenium Mitigating Lead Toxicity in Chickens via Mitochondrial Pathway: Selenoproteins, Oxidative Stress, HSPs, and Apoptosis.

Weichen Hong, Yuhao Liu, Jiatian Liang, Chunyu Jiang, Meijin Yu, Wei Sun, Bin Huang, Na Dong, Lu Kang, You Tang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Toxics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 22 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Weichen HongCollege of Animal Science and Technology, Northeast Agricultural University, Harbin 150030, China.
Yuhao LiuCollege of Animal Science and Technology, Northeast Agricultural University, Harbin 150030, China.
Jiatian LiangCollege of Animal Science and Technology, Northeast Agricultural University, Harbin 150030, China.
Chunyu JiangCollege of Animal Science and Technology, Northeast Agricultural University, Harbin 150030, China.
Meijin YuCollege of Animal Science and Technology, Northeast Agricultural University, Harbin 150030, China.
Wei SunCollege of Animal Science and Technology, Northeast Agricultural University, Harbin 150030, China.
Bin HuangElectrical and Information Engineering College, Jilin Agricultural Science and Technology University, Jilin City 132101, China.
Na DongCollege of Animal Science and Technology, Northeast Agricultural University, Harbin 150030, China.
Lu KangInstitute of Agricultural Quality Standards and Testing Technology, Xinjiang Academy of Agricultural Sciences, Urumqi 830091, China.ORCID 0000-0001-8822-5818
You TangElectrical and Information Engineering College, Jilin Agricultural Science and Technology University, Jilin City 132101, China.
Northeast Agricultural University · CNJilin Agricultural Science and Technology University · CNXinjiang Academy of Agricultural Sciences · CN

Funding

Academic Backbone fund of Northeast Agricultural University 20XG29National Natural Science Foundation of China 31972612Postdoctoral scientific research developmental fund of Heilongjiang Province LBH-Z22066Science and Technology Development Plan Project of Jilin Province YDZJ202201ZYTS692the Tianshan Talent Plan of Xinjiang Uygur Autonomous Region Phase III 2021-2023
6 · The paper itself

Abstract

Lead (Pb), a hazardous heavy metal, can damage the health of organisms. However, it is not clear whether Pb can damage chicken cerebellums and thalami. Selenium (Se), an essential nutrient for organisms, has a palliative effect on Pb poisoning in chickens. In our experiment, a model of chickens treated with Pb and Se alone and in combination was established to investigate the molecular mechanism of Se alleviating Pb-caused damage in both chicken cerebellums and thalami. Our morphological results indicated that Pb caused apoptotic lesions, such as mitochondrial and nuclear damage. Further, the anti-apoptotic gene Bcl-2 decreased; on the contrary, four pro-apoptotic genes (p53, Bax, Cyt c, and Caspase-3) increased under Pb treatment, meaning that Pb caused apoptosis via the p53-Cyt c-Caspase-3 pathway. Furthermore, we further demonstrated that Pb elevated four HSPs (HSP27, HSP40, HSP70, and HSP90), as well as HSP70 took part in the molecular mechanism of Pb-caused apoptosis. In addition, we found that Pb exposure led to oxidative stress via up-regulating the oxidant H

Indexed as

apoptosisHSPsleadmitochondrial pathwayoxidative stressseleniumTxnrds

Identifiers

PMID37755744
PMCPMC10536545
OpenAlexW4386224533

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.