Evidence map›Paper›PMID 37755680›Full record

ArticleJournal of cancer survivorship : research and practice2025

The course of self-perceived cognitive functioning among patients with lymphoma and the co-occurrence with fatigue and psychological distress.

Afke Ekels, Simone Oerlemans, Sanne B Schagen, Djamila E Issa, Noortje Thielen, Marten R Nijziel, Marjolein W M van der Poel, Lindy P J Arts, Eduardus F M Posthuma, Lonneke V van de Poll-Franse

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Article in Journal of cancer survivorship : research and practice, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

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5citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Afke EkelsDepartment of Research and Development, Netherlands Comprehensive Cancer Organisation (IKNL), Utrecht, the Netherlands. a.ekels@IKNL.nl.
Simone OerlemansDepartment of Research and Development, Netherlands Comprehensive Cancer Organisation (IKNL), Utrecht, the Netherlands. s.oerlemans@IKNL.nl.
Sanne B SchagenDivision of Psychosocial Research and Epidemiology, Netherlands Cancer Institute, Amsterdam, the Netherlands.
Djamila E IssaDepartment of Internal Medicine, Jeroen Bosch Hospital, S-Hertogenbosch, the Netherlands.
Noortje ThielenDepartment of Internal Medicine, Diakonessenhuis, Utrecht, the Netherlands.
Marten R NijzielDepartment of Hemato-Oncology, Catharina Cancer Institute, Catharina Hospital, Eindhoven, the Netherlands.
Marjolein W M van der PoelDepartment of Internal Medicine, Division of Hematology, GROW School for Oncology and Developmental Biology, Maastricht University Medical Center, Maastricht, the Netherlands.
Lindy P J ArtsDepartment of Psychology, Revalis Clinics, S-Hertogenbosch, the Netherlands.
Eduardus F M PosthumaDepartment of Research and Development, Netherlands Comprehensive Cancer Organisation (IKNL), Utrecht, the Netherlands.
Lonneke V van de Poll-FranseDepartment of Research and Development, Netherlands Comprehensive Cancer Organisation (IKNL), Utrecht, the Netherlands.

Funding

Nederlandse Organisatie voor Wetenschappelijk Onderzoek 480-08-009
6 · The paper itself

Abstract

purposeTo investigate the proportion of patients with lymphoma with persistent clinically relevant cognitive impairment, and its relation to  treatment, fatigue, and psychological distress.

methodsPatients with diffuse-large-B-cell-lymphoma (DLBCL), follicular-lymphoma (FL), and chronic-lymphocytic-leukemia (CLL)/small-lymphocytic-lymphoma (SLL), diagnosed between 2004-2010 or 2015-2019, were followed up to 8 years post-diagnosis. Sociodemographic and clinical data were obtained from the Netherlands Cancer Registry and the Population-based HAematological Registry for Observational Studies. The EORTC QLQ-C30 was used to assess cognitive functioning and fatigue, and the HADS to assess psychological distress. Individual growth curve models were performed. Results were compared with an age- and sex-matched normative population.

resultsA total of 924 patients were included (70% response rate). Persistent cognitive impairment was twice as high in patients (30%) compared to the normative population (15%). Additionally, 74% of patients reported co-occurring symptoms of persistent fatigue and/or psychological distress. Patients with FL (- 23 points, p < 0.001) and CLL/SLL (- 10 points, p < 0.05) reported clinically relevant deterioration of cognitive functioning, as did the normative population (FLnorm - 5 points, DLBCLnorm - 4 points, both p < 0.05). Younger age, higher fatigue, and/or psychological distress at inclusion were associated with worse cognitive functioning (all p's < 0.01). Treatment appeared less relevant.

conclusionAlmost one-third of patients with lymphoma report persistent cognitive impairment, remaining present up to 8 years post-diagnosis. Early onset and co-occurrence of symptoms highlight the need for clinicians to discuss symptoms with patients early. IMPLICATIONS FOR CANCER SURVIVORS: Early recognition of cognitive impairment could increase timely referral to suitable supportive care (i.e., lifestyle interventions) and reduce (long-term) symptom burden.

Indexed as

Cancer SurvivorsCognitive DysfunctionFatigueLymphomaPsychological DistressAdultAgedAged, 80 and overCognitionFemaleHumansMaleMiddle AgedNetherlandsCognitionLymphomaPatient-reported outcomePopulation-based registryQuality of life

Identifiers

PMID37755680

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