Evidence map›Paper›PMID 37755616›Full record

ReviewMedical oncology (Northwood, London, England)2023

How gallic acid regulates molecular signaling: role in cancer drug resistance.

Samira Hassani, Fahimeh Ghanbari, Marzieh Lotfi, Waqas Alam, Michael Aschner, Jelena Popović-Djordjević, Seyed Hossein Shahcheraghi, Haroon Khan

Abstract readReview
PubMed Publisher
In one paragraph

Review in Medical oncology (Northwood, London, England), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
3.8field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 21 citations in OpenAlex.

  1. Review
  2. Network Pharmacology and Molecular Docking ofInternational journal of molecular sciences · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Investigation ofPlants (Basel, Switzerland) · 2024
    Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 6 institutions in 4 countries.

Samira HassaniDepartment of Plant and Animal Biology, Faculty of Biological Science and Technology, University of Isfahan, Isfahan, Iran.
Fahimeh GhanbariApplied Physiology Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
Marzieh LotfiAbortion Research Center, Reproductive Sciences Institute, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Waqas AlamDepartment of Pharmacy, Abdul Wali Khan University Mardan, Mardan, 23200, Pakistan.
Michael AschnerDepartment of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY, 10461, USA.
Jelena Popović-DjordjevićFaculty of Agriculture, Department for Chemistry and Biochemistry, University of Belgrade, Nemanjina 6, 11080, Belgrade, Serbia.
Seyed Hossein ShahcheraghiDepartment of Medical Genetics, School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. shahcheraghih@gmail.com.
Haroon KhanDepartment of Pharmacy, Abdul Wali Khan University Mardan, Mardan, 23200, Pakistan. haroonkhan@awkum.edu.pk.ORCID http://orcid.org/0000-0002-1736-4404
Abdul Wali Khan University Mardan · PKShahid Sadoughi University of Medical Sciences and Health Services · IRAlbert Einstein College of Medicine · USIsfahan University of Medical Sciences · IRUniversity of Belgrade · RSUniversity of Isfahan · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cancer is one of the deadliest and most heterogeneous diseases. Cancers often develop drug resistance, which can lead to treatment failure or recurrence. Accordingly, anticancer compounds are essential for chemotherapy-resistant cancer cells. Phenolic compounds are of interest in the development of cancer drugs due to their medicinal properties and ability to target different molecular pathways. Gallic acid (GA), as one of the main components of phenol, which is abundantly present in plant compounds such as walnut, sumac, grapes, tea leaves, oak bark, and other plant compounds, has antitumor properties. GA can prevent cancer progression, cell invasion, and metastasis by targeting molecular pathways and is an effective complement to chemotherapy drugs and combating multidrug resistance (MDR). In this review, we discuss various mechanisms related to cancer, the therapeutic potential of GA, the antitumor properties of GA in various cancers, and the targeted delivery of GA with nanocarriers.

Indexed as

Antineoplastic AgentsNeoplasmsDrug Resistance, NeoplasmGallic AcidHumansSignal TransductionAntineoplastic AgentsGallic AcidCancerDrug resistanceGallic acidMolecular pathway

Identifiers

PMID37755616
OpenAlexW4387077516

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.