Evidence map›Paper›PMID 37755540›Full record

ArticleJournal of ophthalmic inflammation and infection2023

Branch retinal vein occlusion in a case of recalcitrant diffuse anterior scleritis treated with tofacitinib.

Anitha Manoharan, Harshita Atmakur, Parthopratim Dutta Majumder, Jyotirmay Biswas

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of ophthalmic inflammation and infection, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
3.0field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 12 citations in OpenAlex.

  1. Observational
  2. Tofacitinib in uveitis and scleritis.Oman journal of ophthalmology
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Anitha ManoharanDepartment of Uvea, Sankara Nethralaya, 41, College Road, Nungambakkam, Chennai, 600006, India.
Harshita AtmakurDepartment of Uvea, Sankara Nethralaya, 41, College Road, Nungambakkam, Chennai, 600006, India.
Parthopratim Dutta MajumderDepartment of Uvea, Sankara Nethralaya, 41, College Road, Nungambakkam, Chennai, 600006, India.
Jyotirmay BiswasDirector of Uveitis and Ocular Pathology Department, Sankara Nethralaya, 41, College Road, Nungambakkam, Chennai, 600006, India. drjb@snmail.org.
Sankara Nethralaya · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A 47-year-old woman with hypertension and rheumatoid arthritis presented with non-necrotizing scleritis in both eyes. Despite a course of oral corticosteroids, she continued to experience persistent symptoms. A rheumatologist was consulted and initiated treatment with tofacitinib, a JAK/STAT inhibitor. Treatment with tofacitinib and oral corticosteroids resulted in an improvement in the scleritis in both eyes. However, a fundus examination of her left eye revealed a superior-temporal branch retinal vein occlusion. Given the growing concern regarding the increased risk of thromboembolic events with tofacitinib therapy, it is essential to consider the risk of retinal vascular occlusions when starting tofacitinib therapy, particularly in patients with underlying systemic comorbidities.

Indexed as

JAK/STAT inhibitorsNon-necrotizing scleritisRecalcitrant scleritisTofacitinib

Identifiers

PMID37755540
PMCPMC10533758
OpenAlexW4387078124

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.