Evidence map›Paper›PMID 37755283›Full record

ArticleMetabolites2023

A Basic Study of the Effects of Mulberry Leaf Administration to Healthy C57BL/6 Mice on Gut Microbiota and Metabolites.

Li Gan, Yuga Inamura, Yu Shimizu, Yuki Yokoi, Yuki Ohnishi, Zihao Song, Yasuhiro Kumaki, Takashi Kikukawa, Makoto Demura, Masaaki Ito and 3 more

Open access · goldAbstract read
In one paragraph

Article in Metabolites, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.8field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
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  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

Li GanLaboratory of Protein Science, Graduate School of Life Science, Hokkaido University, Sapporo 060-0810, Hokkaido, Japan.ORCID 0009-0002-7517-3478
Yuga InamuraLaboratory of Protein Science, Graduate School of Life Science, Hokkaido University, Sapporo 060-0810, Hokkaido, Japan.
Yu ShimizuInnate Immunity Laboratory, Faculty of Advanced Life Science, Hokkaido University, Sapporo 001-0021, Hokkaido, Japan.
Yuki YokoiInnate Immunity Laboratory, Faculty of Advanced Life Science, Hokkaido University, Sapporo 001-0021, Hokkaido, Japan.ORCID 0000-0002-8077-3200
Yuki OhnishiLaboratory of Protein Science, Graduate School of Life Science, Hokkaido University, Sapporo 060-0810, Hokkaido, Japan.
Zihao SongLaboratory of Protein Science, Graduate School of Life Science, Hokkaido University, Sapporo 060-0810, Hokkaido, Japan.ORCID 0000-0003-4976-5832
Yasuhiro KumakiLaboratory of Protein Science, Graduate School of Life Science, Hokkaido University, Sapporo 060-0810, Hokkaido, Japan.
Takashi KikukawaLaboratory of Biological Information Analysis Science, Faculty of Advanced Life Science, Hokkaido University, Sapporo 060-0810, Hokkaido, Japan.
Makoto DemuraLaboratory of Biological Information Analysis Science, Faculty of Advanced Life Science, Hokkaido University, Sapporo 060-0810, Hokkaido, Japan.
Masaaki ItoNational Institute of Technology, Okinawa College, Nago 905-2192, Okinawa, Japan.
Tokiyoshi AyabeInnate Immunity Laboratory, Faculty of Advanced Life Science, Hokkaido University, Sapporo 001-0021, Hokkaido, Japan.ORCID 0000-0002-8631-5593
Kiminori NakamuraInnate Immunity Laboratory, Faculty of Advanced Life Science, Hokkaido University, Sapporo 001-0021, Hokkaido, Japan.
Tomoyasu AizawaLaboratory of Protein Science, Graduate School of Life Science, Hokkaido University, Sapporo 060-0810, Hokkaido, Japan.ORCID 0000-0001-9134-7576
Hokkaido University · JPNational Institute of Technology Okinawa College · JP

Funding

Japan Society for the Promotion of Science JPMJCE1301Japan Society for the Promotion of Science JPMJPF2108Japan Society for the Promotion of Science JPMJSP2119
6 · The paper itself

Abstract

Mulberry leaves contain α-glucosidase inhibitors, which have hypoglycemic effects and are considered functional foods. However, few reports have covered the effects of mulberry leaf components on normal gut microbiota and gut metabolites. Herein, gut microbiota analysis and NMR-based metabolomics were performed on the feces of mulberry leaf powder (MLP)-treated mice to determine the effects of long-term MLP consumption. Gut microbiota in the mouse were analyzed using 16S-rRNA gene sequencing, and no significant differences were revealed in the diversity and community structure of the gut microbiota in the C57BL/6 mice with or without MLP supplementation. Thirty-nine metabolites were identified via

Indexed as

C57BL/6 micegut microbiotametabolomicsmulberry leafNMR spectroscopy

Identifiers

PMID37755283
PMCPMC10535692
OpenAlexW4386719282

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.