Evidence map›Paper›PMID 37755276›Full record

ArticleMetabolites2023

Vitamin D and Its Metabolites Status before and during Chemotherapy in Caucasian Breast Cancer Patients.

Małgorzata Kimsa-Furdzik, Anna Bednarek, Grzegorz Hibner, Paulina Czajka-Francuz, Sylwia Cisoń-Jurek, Dobromiła Karawasiecka, Bożena Szymczak, Jerzy Wojnar, Jerzy Chudek, Tomasz Francuz

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Metabolites, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Małgorzata Kimsa-FurdzikDepartment of Biochemistry, Faculty of Medical Sciences in Katowice, Medical University of Silesia, Medyków 18 St., 40-752 Katowice, Poland.
Anna Bednarek1st Department of Cardiology, Medical University of Silesia, 47 Ziołowa St., 40-635 Katowice, Poland.ORCID 0000-0002-6997-9574
Grzegorz HibnerDepartment of Biochemistry, Faculty of Medical Sciences in Katowice, Medical University of Silesia, Medyków 18 St., 40-752 Katowice, Poland.ORCID 0000-0002-1680-4607
Paulina Czajka-FrancuzDepartment of Internal Medicine and Oncological Chemotherapy, Faculty of Medical Sciences in Katowice, Medical University of Silesia, Reymonta 8 St., 40-027 Katowice, Poland.ORCID 0000-0003-1486-5630
Sylwia Cisoń-JurekDepartment of Internal Medicine and Oncological Chemotherapy, Faculty of Medical Sciences in Katowice, Medical University of Silesia, Reymonta 8 St., 40-027 Katowice, Poland.
Dobromiła KarawasieckaDepartment of Internal Medicine and Oncological Chemotherapy, Faculty of Medical Sciences in Katowice, Medical University of Silesia, Reymonta 8 St., 40-027 Katowice, Poland.
Bożena SzymczakDepartment of Internal Medicine and Oncological Chemotherapy, Faculty of Medical Sciences in Katowice, Medical University of Silesia, Reymonta 8 St., 40-027 Katowice, Poland.
Jerzy WojnarDepartment of Internal Medicine and Oncological Chemotherapy, Faculty of Medical Sciences in Katowice, Medical University of Silesia, Reymonta 8 St., 40-027 Katowice, Poland.
Jerzy ChudekDepartment of Internal Medicine and Oncological Chemotherapy, Faculty of Medical Sciences in Katowice, Medical University of Silesia, Reymonta 8 St., 40-027 Katowice, Poland.ORCID 0000-0002-6367-7794
Tomasz FrancuzDepartment of Biochemistry, Faculty of Medical Sciences in Katowice, Medical University of Silesia, Medyków 18 St., 40-752 Katowice, Poland.ORCID 0000-0002-6321-6090
Medical University of Silesia · PL

Funding

Medical University of Silesia in Katowice PCN-1-026/N/1/0
6 · The paper itself

Abstract

backgroundThe predictive role of vitamin D (VD) in breast cancer (BC) patients' survival is still being investigated. This paper aims to evaluate the changes in VD metabolites during chemotherapy (CTH) and the predictive role of VD status in Caucasian BC patients treated with CTH.

methodsVitamin D and its metabolites were assessed with reference LC-MS/MS methodology in 98 consecutive BC patients starting CHT, after 3 and 6 months, and compared to the control group.

resultsThe frequency of VD deficiency in BC patients was greater than in the control group (56.1% vs. 37.2%). After 6 months of CTH, the number of VD-deficient BC patients slightly increased to 60%. The concentrations of VD active forms [25(OH)D

conclusions(1) Our data provide further evidence that BC patients before CTH are more VD-deficient than the general population and this deficiency increases further during CTH treatment, as observed using the reference LC-MS methodology. (2) Presented results show that VD catabolism is not affected in BC patients. (3) The poorer survival in VD-deficient BP patients supports the importance of VD supplementation in BC patients with 25(OH)D levels below 20 ng/mL.

Indexed as

breast cancercatabolismliquid chromatography/tandem mass spectrometry (LC–MS/MS)metabolitessurvivalvitamin D

Identifiers

PMID37755276
PMCPMC10534610
OpenAlexW4386492827

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.