Evidence map›Paper›PMID 37755094›Full record

ArticleMarine drugs2023

Spatial Distribution and Biochemical Characterization of Serine Peptidase Inhibitors in the Venom of the Brazilian Sea Anemone

Daiane Laise da Silva, Rodrigo Valladão, Emidio Beraldo-Neto, Guilherme Rabelo Coelho, Oscar Bento da Silva Neto, Hugo Vigerelli, Adriana Rios Lopes, Brett R Hamilton, Eivind A B Undheim, Juliana Mozer Sciani and 1 more

Open access · goldAbstract read
In one paragraph

Article in Marine drugs, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.9field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Cnidarian toxins: omics approaches and recombinant proteins.The journal of venomous animals and toxins including tropical diseases · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 3 countries.

Daiane Laise da SilvaPrograma de Pós-Graduação em Ciências-Toxinologia, Instituto Butantan, Av. Vital Brasil 1500, Butantã, São Paulo 05503-900, Brazil.ORCID 0000-0002-8401-7883
Rodrigo ValladãoLaboratório de Bioquímica, Instituto Butantan, Av. Vital Brasil 1500, São Paulo 05503-900, Brazil.
Emidio Beraldo-NetoPrograma de Pós-Graduação em Ciências-Toxinologia, Instituto Butantan, Av. Vital Brasil 1500, Butantã, São Paulo 05503-900, Brazil.ORCID 0000-0002-4735-5162
Guilherme Rabelo CoelhoPrograma de Pós-Graduação em Ciências-Toxinologia, Instituto Butantan, Av. Vital Brasil 1500, Butantã, São Paulo 05503-900, Brazil.ORCID 0000-0002-9633-7219
Oscar Bento da Silva NetoLaboratório de Bioquímica, Instituto Butantan, Av. Vital Brasil 1500, São Paulo 05503-900, Brazil.
Hugo VigerelliPrograma de Pós-Graduação em Ciências-Toxinologia, Instituto Butantan, Av. Vital Brasil 1500, Butantã, São Paulo 05503-900, Brazil.ORCID 0000-0002-8197-2260
Adriana Rios LopesPrograma de Pós-Graduação em Ciências-Toxinologia, Instituto Butantan, Av. Vital Brasil 1500, Butantã, São Paulo 05503-900, Brazil.
Brett R HamiltonCentre for Microscopy and Microanalysis, University of Queensland, St. Lucia, QLD 4072, Australia.
Eivind A B UndheimCentre for Advanced Imaging, University of Queensland, St. Lucia, QLD 4072, Australia.ORCID 0000-0002-8667-3999
Juliana Mozer ScianiLaboratório de Farmacologia Molecular e Compostos Bioativos, Universidade São Francisco, Av. São Francisco de Assis, 218, São Paulo 12916-900, Brazil.ORCID 0000-0001-7213-206X
Daniel Carvalho PimentaPrograma de Pós-Graduação em Ciências-Toxinologia, Instituto Butantan, Av. Vital Brasil 1500, Butantã, São Paulo 05503-900, Brazil.ORCID 0000-0003-2406-0860
Instituto Butantan · BRThe University of Queensland · AUUniversidade São Francisco · BR

Funding

Coordenação de Aperfeicoamento de Pessoal de Nível Superior 88881.362036/2019-01Coordenação de Aperfeicoamento de Pessoal de Nível Superior 88882.442324/2019-01National Council for Scientific and Technological Development 301974/2019-5São Paulo Research Foundation 2018/13588-0
6 · The paper itself

Abstract

Sea anemones are known to produce a diverse array of toxins with different cysteine-rich peptide scaffolds in their venoms. The serine peptidase inhibitors, specifically Kunitz inhibitors, are an important toxin family that is believed to function as defensive peptides, as well as prevent proteolysis of other secreted anemone toxins. In this study, we isolated three serine peptidase inhibitors named

Indexed as

Cnidarian VenomsSea AnemonesSerine Proteinase InhibitorsAmino Acid SequenceAnimalsBrazilChromatography, High Pressure LiquidMass SpectrometryPeptidesCnidarian VenomsPeptidesSerine Proteinase Inhibitorsmass spectrometry imagingsea anemonesserine peptidase inhibitorsvenom

Identifiers

PMID37755094
PMCPMC10532579
OpenAlexW4386328067

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.