Evidence map›Paper›PMID 37755078›Full record

ArticleMarine drugs2023

Butanolides and Butenolides from a Marine-Derived

Paolo Giaccio, Despoina Charou, Dafni-Ioanna Diakaki, Anna Chita, Achille Gravanis, Ioannis Charalampopoulos, Vassilios Roussis, Efstathia Ioannou

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Marine drugs, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.8field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Paolo GiaccioSection of Pharmacognosy and Chemistry of Natural Products, Department of Pharmacy, National and Kapodistrian University of Athens, Panepistimiopolis Zografou, 15771 Athens, Greece.ORCID 0000-0002-3314-9990
Despoina CharouDepartment of Pharmacology, Medical School, University of Crete, 71003 Heraklion, Greece.
Dafni-Ioanna DiakakiSection of Pharmacognosy and Chemistry of Natural Products, Department of Pharmacy, National and Kapodistrian University of Athens, Panepistimiopolis Zografou, 15771 Athens, Greece.
Anna ChitaDepartment of Pharmacology, Medical School, University of Crete, 71003 Heraklion, Greece.ORCID 0009-0001-6211-0403
Achille GravanisDepartment of Pharmacology, Medical School, University of Crete, 71003 Heraklion, Greece.
Ioannis CharalampopoulosDepartment of Pharmacology, Medical School, University of Crete, 71003 Heraklion, Greece.ORCID 0000-0003-3415-7332
Vassilios RoussisSection of Pharmacognosy and Chemistry of Natural Products, Department of Pharmacy, National and Kapodistrian University of Athens, Panepistimiopolis Zografou, 15771 Athens, Greece.ORCID 0000-0001-9856-4725
Efstathia IoannouSection of Pharmacognosy and Chemistry of Natural Products, Department of Pharmacy, National and Kapodistrian University of Athens, Panepistimiopolis Zografou, 15771 Athens, Greece.ORCID 0000-0003-3103-4951
National and Kapodistrian University of Athens · GRUniversity of Crete · GR

Funding

European Union's Horizon 2020 Marie Skłodowska-Curie grant agreement No 765704
6 · The paper itself

Abstract

Neurodegenerative diseases are incurable and debilitating conditions, characterized by progressive loss and degeneration of vulnerable neuronal populations. Currently, there are no effective therapies available for the treatment of most neurodegenerative disorders. A panel of extracts exhibiting interesting chemical profiles among a high number of bacterial strains isolated from East Mediterranean marine sediments and macroorganisms were evaluated for their activity on TrkB-expressing cells. Among them, the actinobacterial strain

Indexed as

4-ButyrolactoneNeuroprotective AgentsReceptor, trkBStreptomycesAnimalsAquatic OrganismsBrain-Derived Neurotrophic FactorCell SurvivalMiceNeuronsNIH 3T3 Cells4-ButyrolactoneBrain-Derived Neurotrophic FactorbutenolideNeuroprotective AgentsReceptor, trkBBDNFmarine actinobacterianeurodegenerative diseasesneuroprotectionStreptomycesTrkB receptorγ-lactones

Identifiers

PMID37755078
PMCPMC10532803
OpenAlexW4386168712

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.