Evidence map›Paper›PMID 37754981›Full record

ArticleJournal of fungi (Basel, Switzerland)2023

Pitaya Juice Consumption Protects against Oxidative Damage Induced by Aflatoxin B1.

Luiggi Müller Madalosso, Franciéle Romero Machado Balok, Vandreza Cardoso Bortolotto, Mustafa Munir Mustafa Dahleh, Lucas Gabriel Backes, Elizabeth Sabryna Sarquis Escalante, Fernanda Vilhalba Benites, Francisco Andrey da Silva E Silva, Hecson Jesser Segat, Silvana Peterini Boeira

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of fungi (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.8field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Luiggi Müller MadalossoLaboratory of Pharmacological and Toxicological Evaluations Applied to Bioactives Molecules-LaftamBio, Federal University of Pampa, Itaqui 97650-000, Brazil.
Franciéle Romero Machado BalokPrograma de Pós-Graduação em Bioquímica, Federal University of Pampa, Uruguaiana 97650-000, Brazil.
Vandreza Cardoso BortolottoPrograma de Pós-Graduação em Bioquímica, Federal University of Pampa, Uruguaiana 97650-000, Brazil.ORCID 0000-0002-3043-1843
Mustafa Munir Mustafa DahlehPrograma de Pós-Graduação em Bioquímica, Federal University of Pampa, Uruguaiana 97650-000, Brazil.ORCID 0000-0002-5850-6739
Lucas Gabriel BackesLaboratory of Pharmacological and Toxicological Evaluations Applied to Bioactives Molecules-LaftamBio, Federal University of Pampa, Itaqui 97650-000, Brazil.ORCID 0000-0002-2891-9321
Elizabeth Sabryna Sarquis EscalanteLaboratory of Pharmacological and Toxicological Evaluations Applied to Bioactives Molecules-LaftamBio, Federal University of Pampa, Itaqui 97650-000, Brazil.
Fernanda Vilhalba BenitesLaboratory of Pharmacological and Toxicological Evaluations Applied to Bioactives Molecules-LaftamBio, Federal University of Pampa, Itaqui 97650-000, Brazil.
Francisco Andrey da Silva E SilvaLaboratory of Pharmacological and Toxicological Evaluations Applied to Bioactives Molecules-LaftamBio, Federal University of Pampa, Itaqui 97650-000, Brazil.
Hecson Jesser SegatLaboratory of Pharmacological and Toxicological Evaluations Applied to Bioactives Molecules-LaftamBio, Federal University of Pampa, Itaqui 97650-000, Brazil.
Silvana Peterini BoeiraLaboratory of Pharmacological and Toxicological Evaluations Applied to Bioactives Molecules-LaftamBio, Federal University of Pampa, Itaqui 97650-000, Brazil.
Universidade Federal do Pampa · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mycotoxins are toxic fungal metabolites and are responsible for contaminating several foods. The intake of foods contaminated by these substances is related to hepatotoxicity and carcinogenic effects, possibly due to increasing oxidative stress. The current study evaluated Pitaya fruit juice's antioxidant effects on oxidative damage aflatoxin B1 (AFB1)-induced. Rats received 1.5 mL of Pitaya juice via gavage (for 30 days), and on the 31st day, they received AFB1 (250 µg/kg, via gavage). Forty-eight hours after the AFB1 dose, rats were euthanized for dosages of alanine transaminase (ALT), aspartate aminotransferase (AST), and alkaline phosphatase (ALP); dosage of oxidative markers (thiobarbituric acid reactive species (TBARS), reactive species (RS)) and antioxidant defenses (catalase (CAT), superoxide dismutase (SOD), Glutathione S-transferase (GST) activities and Glutathione (GSH)) levels in the liver; and detection of Heat shock protein 70 (Hsp-70) and nuclear factor- erythroid 2-related factor 2 (Nrf2) immunocontent in the liver. Our results indicated that the Pitaya juice reduced ALP activity. Further, rats exposed to AFB1 experienced liver damage due to the increase in TBARS, RS, and Hsp-70 and the reduction in CAT, GSH, and Nrf2. Pitaya juice could, however, protect against these damages. Finally, these results indicated that pre-treatment with Pitaya juice was effective against the oxidative damage induced. However, other aspects may be elucidated in the future to discover more targets of its action against mycotoxicosis.

Indexed as

antioxidant effectshepatotoxicitymycotoxin

Identifiers

PMID37754981
PMCPMC10532851
OpenAlexW4386121782

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.