Evidence map›Paper›PMID 37754938›Full record

ArticleJournal of imaging2023

3D Ultrasound and MRI in Assessing Resection Margins during Tongue Cancer Surgery: A Research Protocol for a Clinical Diagnostic Accuracy Study.

Fatemeh Makouei, Tina Klitmøller Agander, Caroline Ewertsen, Morten Bo Søndergaard Svendsen, Rikke Norling, Mikkel Kaltoft, Adam Espe Hansen, Jacob Høygaard Rasmussen, Irene Wessel, Tobias Todsen

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of imaging, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06314711 (Tumor Volume and Margin Assessment with Ex Vivo 3D-ultrasound After Transoral Robotic Surgery for Oropharyngeal Squamous Cell Carcinoma), which is not on this map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06314711 nacompletednot on this map

Tumor Volume and Margin Assessment with Ex Vivo 3D-ultrasound After Transoral Robotic Surgery for Oropharyngeal Squamous Cell Carcinoma

TypeinterventionalSponsorRigshospitalet, DenmarkRan2021 to 2024Enrolled15ConditionsOropharyngeal Squamous Cell CarcinomaArmsUltrasound
3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Fatemeh MakoueiDepartment of Otorhinolaryngology, Head and Neck Surgery and Audiology, Rigshospitalet, Copenhagen University Hospital, DK-2100 Copenhagen, Denmark.ORCID 0000-0002-6443-7362
Tina Klitmøller AganderDepartment of Pathology, Rigshospitalet, Copenhagen University Hospital, DK-2100 Copenhagen, Denmark.
Caroline EwertsenInstitute of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 3, DK-2200 Copenhagen, Denmark.
Morten Bo Søndergaard SvendsenCopenhagen Academy for Medical Education and Simulation, The Capital Region of Denmark, DK-2100 Copenhagen, Denmark.
Rikke NorlingDepartment of Radiology, Rigshospitalet, Copenhagen University Hospital, DK-2100 Copenhagen, Denmark.
Mikkel KaltoftDepartment of Otorhinolaryngology, Head and Neck Surgery and Audiology, Rigshospitalet, Copenhagen University Hospital, DK-2100 Copenhagen, Denmark.ORCID 0009-0000-1900-3445
Adam Espe HansenInstitute of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 3, DK-2200 Copenhagen, Denmark.ORCID 0000-0002-6457-1537
Jacob Høygaard RasmussenDepartment of Otorhinolaryngology, Head and Neck Surgery and Audiology, Rigshospitalet, Copenhagen University Hospital, DK-2100 Copenhagen, Denmark.
Irene WesselDepartment of Otorhinolaryngology, Head and Neck Surgery and Audiology, Rigshospitalet, Copenhagen University Hospital, DK-2100 Copenhagen, Denmark.
Tobias TodsenDepartment of Otorhinolaryngology, Head and Neck Surgery and Audiology, Rigshospitalet, Copenhagen University Hospital, DK-2100 Copenhagen, Denmark.
University of Copenhagen · DKCopenhagen University Hospital · DK

Funding

Innofoundation - InnoExplorer 2054-00019B
6 · The paper itself

Abstract

Surgery is the primary treatment for tongue cancer. The goal is a complete resection of the tumor with an adequate margin of healthy tissue around the tumor.Inadequate margins lead to a high risk of local cancer recurrence and the need for adjuvant therapies. Ex vivo imaging of the resected surgical specimen has been suggested for margin assessment and improved surgical results. Therefore, we have developed a novel three-dimensional (3D) ultrasound imaging technique to improve the assessment of resection margins during surgery. In this research protocol, we describe a study comparing the accuracy of 3D ultrasound, magnetic resonance imaging (MRI), and clinical examination of the surgical specimen to assess the resection margins during cancer surgery. Tumor segmentation and margin measurement will be performed using 3D ultrasound and MRI of the ex vivo specimen. We will determine the accuracy of each method by comparing the margin measurements and the proportion of correctly classified margins (positive, close, and free) obtained by each technique with respect to the gold standard histopathology.

Indexed as

3D ultrasound imagingex vivo surgical specimen imagingmagnetic resonance imagingoral cancersquamous cell carcinoma histopathologysurgical margin assessmenttongue squamous cell carcinoma

Identifiers

PMID37754938
PMCPMC10532641
OpenAlexW4386219447

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.