Evidence map›Paper›PMID 37754866›Full record

ArticleJournal of functional biomaterials2023

A New α + β Ti-15Nb Alloy with Low Elastic Modulus: Characterization and In Vitro Evaluation on Osteogenic Phenotype.

Tatiani Ayako Goto Donato, Karolyne Dos Santos Jorge Sousa, Pedro Akira Bazaglia Kuroda, Carlos Roberto Grandini

Open access · goldAbstract read
In one paragraph

Article in Journal of functional biomaterials, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.8field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 8 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Tatiani Ayako Goto DonatoLaboratório de Anelasticidade e Biomateriais, UNESP-Universidade Estadual Paulista, Bauru 17033-360, SP, Brazil.
Karolyne Dos Santos Jorge SousaLaboratório de Anelasticidade e Biomateriais, UNESP-Universidade Estadual Paulista, Bauru 17033-360, SP, Brazil.
Pedro Akira Bazaglia KurodaLaboratório de Anelasticidade e Biomateriais, UNESP-Universidade Estadual Paulista, Bauru 17033-360, SP, Brazil.
Carlos Roberto GrandiniLaboratório de Anelasticidade e Biomateriais, UNESP-Universidade Estadual Paulista, Bauru 17033-360, SP, Brazil.ORCID 0000-0002-3336-309X
Universidade Estadual Paulista (Unesp) · BRNanomed (Brazil) · BR

Funding

National Council for Scientific and Technological Development #137.221/2015-0National Council for Scientific and Technological Development #157.509/2015-0National Council for Scientific and Technological Development #307.279/2013-8National Council for Scientific and Technological Development #400.705/2015-0São Paulo Research Foundation #2015/25.562-7
6 · The paper itself

Abstract

This study aimed to produce Ti-15Nb alloy with a low elastic modulus, verify its biocompatibility, and determine whether the alloy indirectly influences cellular viability and morphology, as well as the development of the osteogenic phenotype in cells cultured for 2, 3, and 7 days derived from rat calvarias. Two heat treatments were performed to modify the mechanical properties of the alloy where the Ti-15Nb alloy was heated to 1000 °C followed by slow (-5 °C/min) (SC) and rapid cooling (RC). The results of structural and microstructural characterization (XRD and optical images) showed that the Ti-15Nb alloy was of the α + β type, with slow cooling promoting the formation of the α phase and rapid cooling the formation of the β phase, altering the values for the hardness and elastic modulus. Generally, a more significant amount of the α phase in the Ti-15Nb alloy increased the elastic modulus value but decreased the microhardness value. After the RC treatment, the results demonstrated that the Ti-15Nb alloy did not present cytotoxic effects on the osteogenic cells. In addition, we did not find variations in the cell quantity in the microscopy results that could suggest cell adhesion or proliferation modification.

Indexed as

biomaterialcytotoxicityosteogenic cellstitanium alloys

Identifiers

PMID37754866
PMCPMC10531885
OpenAlexW4386378497

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.