Evidence map›Paper›PMID 37754389›Full record

ArticleGels (Basel, Switzerland)2023

Highly Stretchable, Self-Healing, Injectable and pH Responsive Hydrogel from Multiple Hydrogen Bonding and Boron-Carbohydrate Interactions.

Yi-Yang Peng, Qiuli Cheng, Meng Wu, Wenda Wang, Jianyang Zhao, Diana Diaz-Dussan, Michelle McKay, Hongbo Zeng, Sarute Ummartyotin, Ravin Narain

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Gels (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. NHHeliyon · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yi-Yang PengDepartment of Chemical and Materials Engineering, University of Alberta, Edmonton, AB T6G 2G6, Canada.ORCID 0000-0002-3363-4937
Qiuli ChengSchool of Materials Science and Engineering, Henan University of Science and Technology, Luoyang 471023, China.
Meng WuDepartment of Chemical and Materials Engineering, University of Alberta, Edmonton, AB T6G 2G6, Canada.
Wenda WangDepartment of Chemical and Materials Engineering, University of Alberta, Edmonton, AB T6G 2G6, Canada.
Jianyang ZhaoSchool of Biomedical Sciences and Engineering Guangzhou International Campus, South China University of Technology, Guangzhou 511442, China.
Diana Diaz-DussanDepartment of Chemical and Materials Engineering, University of Alberta, Edmonton, AB T6G 2G6, Canada.ORCID 0000-0003-1778-3964
Michelle McKayDepartment of Chemical and Materials Engineering, University of Alberta, Edmonton, AB T6G 2G6, Canada.
Hongbo ZengDepartment of Chemical and Materials Engineering, University of Alberta, Edmonton, AB T6G 2G6, Canada.ORCID 0000-0002-1432-5979
Sarute UmmartyotinDepartment of Materials and Textile Technology, Faculty of Science and Technology, Thammasat University, Pathum Thani 12120, Thailand.
Ravin NarainDepartment of Chemical and Materials Engineering, University of Alberta, Edmonton, AB T6G 2G6, Canada.ORCID 0000-0003-0947-9719

Funding

Natural Sciences and Engineering Research Council NA
6 · The paper itself

Abstract

A simple and cost-effective method for the fabrication of a safe, dual-responsive, highly stretchable, self-healing and injectable hydrogel is reported based on a combination of dynamic boronate ester bonds and hydrogen bonding interactions. The mechanical properties of the hydrogel are tunable by adjusting the molar ratios between sugar moieties on the polymer and borax. It was remarkable to note that the 2:1 ratio of sugar and borate ion significantly improves the mechanical strength of the hydrogel. The injectability, self-healing and stretchability properties of the hydrogel were also examined. In addition, the impact of the variation of the pH and the addition of free sugar responsiveness of the hydrogel was studied. High MRC-5 cell viability was noticed by the 3D live/dead assay after 24 h cell culture within the hydrogel scaffold. Hence, the developed hydrogels have desirable features that warrant their applications for drug delivery, scaffolds for cell and tissue engineering.

Indexed as

boron-carbohydrate interactiondiols responsivenessdrug deliveryglycopolymerhydrogelinjectablepH responsivenessself-healing

Identifiers

PMID37754389
PMCPMC10530767

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.