SynthesisThe journal of nutrition, health & aging2023
Micronutrient Deficiency and Its Potential Role in Delirium Onset in Older Adults: A Systematic Review.
Synthesis in The journal of nutrition, health & aging, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 24 citations in OpenAlex.
- Malnutrition as an independent risk factor for incident delirium in cohort of older adults receiving domiciliary care services.GeroScience · 2026Article
- Observational
- Development and Expert Consensus of an Evidence-Based Strategy to Prevent Postoperative Delirium in Malnourished Cancer Patients.Journal of multidisciplinary healthcare · 2026Article
- Body weight trajectories from midlife are associated with cognitive decline in advanced age.Scientific reports · 2025Article
- Impact of vitamin D levels on mortality in older covid-19 vaccinated patients.BMC geriatrics · 2025Article
- Association between food insecurity and risk of Parkinson's disease: insights from NHANES data.The journal of nutrition, health & aging · 2025Article
- Comparative predictive value of preoperative GNRI, PNI, and CONUT for postoperative delirium in geriatric abdominal surgery patients admitted to the ICU.Frontiers in nutrition · 2025Article
- Bridging nutrition and neurology: malnutrition's role in perioperative neurocognitive disorders.Frontiers in nutrition · 2025Review
- Exploring the role of calf circumference as a predisposing factor for intra-hospital delirium: investigating potential gender differences: revealing potential gender variances.BMC geriatrics · 2024Article
- Article
- Association between dietary vitamin B1 intake and cognitive function among older adults: a cross-sectional study.Journal of translational medicine · 2024Observational
- The causal effects of dietary component intake and blood metabolites on risk of delirium: a Mendelian randomization study.Frontiers in nutrition · 2024Article
- Mechanisms underlying delirium in patients with critical illness.Frontiers in aging neuroscience · 2024Review
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
objectivesOne of the pathogenetic hypotheses of delirium is the "neuroinflammatory theory" with consequent neurotoxicity of brain connectivity networks. Micronutrients may play a significant role in the prevention of neuroinflammation. This systematic review addresses the role of micronutrients in the development of delirium in older populations.
methodsThe EBSCO, Cochrane, PubMed, and Web of Science databases were searched for articles on delirium and micronutrients. The methodological quality of the studies included in the review was evaluated with the Newcastle-Ottawa Scales for observational studies and for case-control studies.
results1326 papers were identified from the searches, 7 of which met the inclusion criteria (see section 2.3). All the papers included were written in English. Delirium was predominantly secondary to post-operative dysfunction or acute medical conditions. By altering the production of neurotransmitters resulting in an imbalance, and by reducing their immunomodulatory role with a consequent increase in inflammatory oxidative stress, micronutrient deficiency seems to be associated with an increased incidence of delirium.
conclusionsThis review supports the existence of an association between micronutrient deficiency (i.e. cobalamin, thiamine, and vitamin D) and an increased incidence of delirium, with a greater prevalence in hospitalized patients.
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