Evidence map›Paper›PMID 37754107›Full record

ArticleBiosensors2023

A Methylene Blue-Enhanced Nanostructured Electrochemical Immunosensor for H-FABP Myocardial Injury Biomarker.

Cecília Maciel Prado, Paula Angélica Burgos Ferreira, Lucas Alves de Lima, Erika Ketlem Gomes Trindade, Rosa Fireman Dutra

Open access · goldAbstract read
In one paragraph

Article in Biosensors, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Cecília Maciel PradoBiomedical Engineering Laboratory, Department of Biomedical Engineering, Federal University of Pernambuco, Av. Prof. Moraes Rego, 1235, Recife 50670-90, Brazil.
Paula Angélica Burgos FerreiraBiomedical Engineering Laboratory, Department of Biomedical Engineering, Federal University of Pernambuco, Av. Prof. Moraes Rego, 1235, Recife 50670-90, Brazil.
Lucas Alves de LimaBiomedical Engineering Laboratory, Department of Biomedical Engineering, Federal University of Pernambuco, Av. Prof. Moraes Rego, 1235, Recife 50670-90, Brazil.
Erika Ketlem Gomes TrindadeBiomedical Engineering Laboratory, Department of Biomedical Engineering, Federal University of Pernambuco, Av. Prof. Moraes Rego, 1235, Recife 50670-90, Brazil.ORCID 0000-0002-3395-3663
Rosa Fireman DutraBiomedical Engineering Laboratory, Department of Biomedical Engineering, Federal University of Pernambuco, Av. Prof. Moraes Rego, 1235, Recife 50670-90, Brazil.ORCID 0000-0001-8314-4218
Universidade Federal de Pernambuco · BR

Funding

Conselho Nacional de Desenvolvimento Científico e Tecnológico do Brasil (CNPq) 311651/2022-4FACEPE - Fundação do Amparo a Ciência de Pernambuco APQ 1550-313/22
6 · The paper itself

Abstract

A sensitive electrochemical immunosensor for the detection of the heart-type fatty acid binding protein (HFABP), an earlier biomarker for acute myocardial infarction than Troponins, is described. The sensing platform was enhanced with methylene blue (MB) redox coupled to carbon nanotubes (CNT) assembled on a polymer film of polythionine (PTh). For this strategy, monomers of thionine rich in amine groups were electrosynthesized by cyclic voltammetry on the immunosensor's gold surface, forming an electroactive film with excellent electron transfer capacity. Stepwise sensor surface preparation was electrochemically characterized at each step and scanning electronic microscopy was carried out showing all the preparation steps. The assembled sensor platform combines MB and PTh in a synergism, allowing sensitive detection of the H-FABP in a linear response from 3.0 to 25.0 ng∙mL

Indexed as

Biosensing TechniquesFatty Acid-Binding ProteinsMyocardial InfarctionBiomarkersElectrochemical TechniquesFatty Acid Binding Protein 3GoldHumansImmunoassayLimit of DetectionMethylene BlueNanostructuresNanotubes, CarbonBiomarkersFABP3 protein, humanFatty Acid Binding Protein 3Fatty Acid-Binding ProteinsGoldMethylene BlueNanotubes, Carbonacute myocardial infarctionH-FABPimmunosensormethylene bluepolythionine

Identifiers

PMID37754107
PMCPMC10526172
OpenAlexW4386496561

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.