Evidence map›Paper›PMID 37753868›Full record

ArticleNanoscale2023

Engineering endosomolytic nanocarriers of diverse morphologies using confined impingement jet mixing.

Hayden M Pagendarm, Payton T Stone, Blaise R Kimmel, Jessalyn J Baljon, Mina H Aziz, Lucinda E Pastora, Lauren Hubert, Eric W Roth, Sultan Almunif, Evan A Scott and 1 more

Open access · hybridAbstract read
In one paragraph

Article in Nanoscale, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.0field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Hayden M PagendarmDepartment of Biomedical Engineering, Vanderbilt University, Nashville, TN 37235, USA. john.t.wilson@vanderbilt.edu.ORCID http://orcid.org/0000-0001-7611-6120
Payton T StoneDepartment of Chemical and Biomolecular Engineering, Vanderbilt University, Nashville, TN 37235, USA.ORCID http://orcid.org/0000-0002-8105-0610
Blaise R KimmelDepartment of Chemical and Biomolecular Engineering, Vanderbilt University, Nashville, TN 37235, USA.ORCID http://orcid.org/0000-0002-9582-9887
Jessalyn J BaljonDepartment of Biomedical Engineering, Vanderbilt University, Nashville, TN 37235, USA. john.t.wilson@vanderbilt.edu.
Mina H AzizDepartment of Biochemistry, Vanderbilt University, Nashville, TN 37235, USA.
Lucinda E PastoraDepartment of Chemical and Biomolecular Engineering, Vanderbilt University, Nashville, TN 37235, USA.
Lauren HubertDepartment of Chemical Engineering, The University of Rhode Island, Kingston, RI 02881, USA.
Eric W RothNUANCE BioCryo, Northwestern University, Evanston, IL 60208, USA.
Sultan AlmunifDepartment of Biomedical Engineering, Northwestern University, Evanston, IL 60208, USA.
Evan A ScottDepartment of Biomedical Engineering, Northwestern University, Evanston, IL 60208, USA.ORCID http://orcid.org/0000-0002-8945-2892
John T WilsonDepartment of Biomedical Engineering, Vanderbilt University, Nashville, TN 37235, USA. john.t.wilson@vanderbilt.edu.ORCID http://orcid.org/0000-0002-9144-2634
Vanderbilt University · USNorthwestern University · USUniversity of Rhode Island · US

Funding

Tumor Immunology and Microenvironment Research ProgramP30CA068485 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Ben Ho Park · 1995 to 2026
$172.8M
Chemistry-Biology Interface Training GrantT32GM065086 · NIGMS · VANDERBILT UNIVERSITY · PI BACHMANN, BRIAN O, SULIKOWSKI, GARY ALLEN · 2002 to 2022
$7.0M
Integrated Training in Engineering and DiabetesT32DK101003 · NIDDK · VANDERBILT UNIVERSITY · PI Jamey D. Young · 2014 to 2026
$3.9M
Design and characterization of biomimetic nanobiomaterials to elicit CD1-restricted T cell responses during sub-unit vaccinationR01AI145345 · NIAID · NORTHWESTERN UNIVERSITY · PI SCOTT, EVAN ALEXANDER, WANG, CHYUNG-RU · 2019 to 2022
$2.9M
Toward Translation of an Immunotherapeutic Nanomedicine for NeuroblastomaR01CA274675 · NCI · VANDERBILT UNIVERSITY · PI John Tanner Wilson · 2022 to 2026
$2.5M
Engineered Vaccines for Neoantigen Targeted Cancer ImmunotherapyR01CA266767 · NCI · VANDERBILT UNIVERSITY · PI John Tanner Wilson · 2022 to 2026
$2.4M
Expanding the Therapeutic Window of Nanoparticle STING Agonists for Cancer ImmunotherapyR01CA245134 · NCI · VANDERBILT UNIVERSITY · PI WILSON, JOHN TANNER · 2020 to 2025
$1.8M
An Engineered Nanocarrier Platform for Enhancing Immune Responses to Neoantigen-Targeted Cancer VaccinesF31CA257275 · NCI · VANDERBILT UNIVERSITY · PI BALJON, JESSALYN J · 2021 to 2023
$120k
NCI NIH HHS F31 CA257275NCI NIH HHS P30 CA068485NCI NIH HHS R01 CA245134NCI NIH HHS R01 CA266767NCI NIH HHS R01 CA274675NIAID NIH HHS R01 AI145345NIDDK NIH HHS T32 DK101003NIGMS NIH HHS T32 GM065086
6 · The paper itself

Abstract

The clinical translation of many biomolecular therapeutics has been hindered by undesirable pharmacokinetic (PK) properties, inadequate membrane permeability, poor endosomal escape and cytosolic delivery, and/or susceptibility to degradation. Overcoming these challenges merits the development of nanoscale drug carriers (nanocarriers) to improve the delivery of therapeutic cargo. Herein, we implement a flash nanoprecipitation (FNP) approach to produce nanocarriers of diverse vesicular morphologies by using various molecular weight PEG-

Indexed as

NanoparticlesPolymersDrug CarriersEndosomesMicellesPolyethylene GlycolsDrug CarriersMicellesPolyethylene GlycolsPolymers

Identifiers

PMID37753868
PMCPMC10568979
OpenAlexW4386871015

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.