Evidence map›Paper›PMID 37753785›Full record

ArticleJournal of the American Heart Association2023

Delayed Diagnosis in Cerebral Venous Thrombosis: Associated Factors and Clinical Outcomes.

Ekaterina Bakradze, Liqi Shu, Nils Henninger, Shyam Prabhakaran, James E Siegler, Gian Marco De Marchis, James A Giles, Tolga Dittrich, Mirjam R Heldner, Kateryna Antonenko and 6 more

Abstract readMulticenter Study
In one paragraph

Article in Journal of the American Heart Association, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Cerebral venous thrombosis: Current management, recent advances and future directions.International journal of stroke : official journal of the International Stroke Society · 2025
    Review
  9. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Ekaterina BakradzeDepartment of Neurology University of Alabama at Birmingham Birmingham AL USA.ORCID 0000-0001-7534-7218
Liqi ShuDepartment of Neurology Brown University Providence RI USA.ORCID 0000-0002-9784-8475
Nils HenningerDepartment of Neurology University of Massachusetts Chan Medical School Worcester MA USA.ORCID 0000-0002-3883-5623
Shyam PrabhakaranDepartment of Neurology University of Chicago Chicago, IL USA.ORCID 0000-0003-0724-1694
James E SieglerCooper Neurological Institute Cooper University Camden NJ USA.ORCID 0000-0003-0287-3967
Gian Marco De MarchisDepartment of Neurology University Hospital Basel and University of Basel Basel Switzerland.ORCID 0000-0002-0342-9780
James A GilesDepartment of Neurology Yale University School of Medicine New Haven CT USA.ORCID 0000-0002-3197-3062
Tolga DittrichDepartment of Neurology University Hospital Basel and University of Basel Basel Switzerland.ORCID 0000-0002-9987-3631
Mirjam R HeldnerDepartment of Neurology University Hospital and University of Bern Bern Switzerland.ORCID 0000-0002-3594-2159
Kateryna AntonenkoDepartment of Neurology University Hospital and University of Bern Bern Switzerland.ORCID 0000-0002-1936-5451
Wayneho KamDepartment of Neurology Duke University Hospital Durham NC USA.ORCID 0000-0002-6639-364X
David S LiebeskindDepartment of Neurology University of California at Los Angeles Los Angeles CA USA.ORCID 0000-0002-5109-8736
Alexis N SimpkinsDepartment of Neurology University of Florida Gainesville FL USA.ORCID 0000-0001-7529-4267
Thanh N NguyenDepartment of Neurology Boston University Chobanian and Avedisian School of Medicine Boston MA USA.ORCID 0000-0003-1448-8791
Shadi YaghiDepartment of Neurology Brown University Providence RI USA.ORCID 0000-0003-0031-1004
Ava L LibermanClinical and Translational Neuroscience Unit, Department of Neurology Feil Family Brain and Mind Research Institute, Weill Cornell Medicine New York NY USA.ORCID 0000-0003-0184-6035

Funding

MOLECULAR GENETICS OF ZEBRAFISH PIGMENT CELL DEVELOPMENTF32NS010764 · NINDS · UNIVERSITY OF WASHINGTON · PI LISTER, JAMES A · 1998 to 2001
$73k
NINDS NIH HHS F32 NS010764
6 · The paper itself

Abstract

Background Identifying factors associated with delayed diagnosis of cerebral venous thrombosis (CVT) can inform future strategies for early detection. Methods and Results We conducted a retrospective cohort study including all participants from ACTION-CVT (Anticoagulation in the Treatment of Cerebral Venous Thrombosis) study who had dates of neurologic symptom onset and CVT diagnosis available. Delayed diagnosis was defined as CVT diagnosis occurring in the fourth (final) quartile of days from symptom onset. The primary study outcome was modified Rankin Scale score of ≤1 at 90 days; secondary outcomes included partial/complete CVT recanalization on last available imaging and modified Rankin Scale score of ≤2. Logistic regression analyses were used to identify independent variables associated with delayed diagnosis and to assess the association of delayed diagnosis and outcomes. A total of 935 patients were included in our study. Median time from symptom onset to diagnosis was 4 days (interquartile range, 1-10 days). Delayed CVT diagnosis (time to diagnosis >10 days) occurred in 212 patients (23%). Isolated headache (adjusted odds ratio [aOR], 2.36 [95% CI, 1.50-3.73];

Indexed as

Intracranial ThrombosisVenous ThrombosisDelayed DiagnosisHeadacheHumansRetrospective StudiesRisk Factorscerebral venous thrombosisdiagnostic errorvenous thromboembolism

Identifiers

PMID37753785
PMCPMC10727263

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.